Constitutional chromosome abnormalities are seen frequently in infertile men. The consequences of these abnormalities in sperm are outlined. Infertile men with a normal chromosome karyotype also have an increased frequency of chromosome abnormalities in their sperm and a review of these...

Since it has been reported that in humans 90% of embryos are aneuploid as a result of malsegregation mechanisms in maternal meiosis I,1 the detection of abnormal oocytes in IVF treatments has become of considerable importance. Taking into account the results obtained from the study of...

Uterine leiomyomata (UL), commonly referred to as fibroids, are the most frequent neoplasm of the female genital tract with such high morbidity as to account annually for one-third of hysterectomies (more than 200,000 procedures), approximately 1 in 5 visits to a gynecologist, and...

Chromosomal abnormalities are common at all stages of human development and are the main cause of lethality between conception and birth. In natural conceptions the fecundity rate is about 25% while each embryo derived from in vitro fertilisation has on average a 1 in 5 chance of survival....

Prenatal diagnoses of chromosome abnormalities are performed by cytogenetic analyses of metaphase chromosomes obtained from fetal cells after several days of in vitro culture. The main disadvantage is that definitive results may take up to two weeks thus increasing parental anxiety or...

Chromosome number abnormalities are remarkably common in human reproduction, as a consequence of both whole chromosome nondisjunction and premature chromatid separation during oocyte meiosis I. Pooled data from previous studies suggests that one in five oocytes that fail to fertilize after...

Chromosome abnormalities have been diagnosed from prenatal specimens for almost 40 years. In the United States, the current standard of care in obstetrical practice is to offer either chorionic villus sampling (CVS) or amniocentesis to women at increased risk for having a fetus with...

Most chromosome abnormalities lead to fetal loss, with the majority of losses occurring very early in gestation. The greater the size of the chromosomal aberration (imbalance), the earlier the fetus is expected to miscarry. There are only a few aneuploidies that survive to term. The most...