FasL and Fas: Typical Members of the TNF Ligand and Receptor Family

Chapter Details

Pub Date: 3 Apr 2006
Pages: 13
Chapter Category: Signal Transduction
Taken from the Book: Fas Signaling
Book Series: Intelligence Unit
Edited by: Harald Wajant

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FasL and Fas: Typical Members of the TNF Ligand and Receptor Family

Anja Krippner-Heidenreich and Peter Scheurich

About this Chapter

The membrane receptor Fas is one of the central members of the TNF receptor superfamily, representing the prototype of an apoptosis inducer. Its cognate ligand, FasL, is expressed as a type II transmembrane protein, but also exists as a soluble molecule. Typical for all members of the receptor superfamily, Fas signaling is induced by multimerization. Both molecules share structural features with their respective family members. Hallmarks of Fas are two and a half copies of a cysteine rich domain in the extracellular part, required for ligand binding and self-association and the intracellular death domain, essential for apoptosis induction. Characteristics of the FasL are the stable formation of homotrimers, each protomer consisting of two ?-sheets in a typical “jelly roll” arrangement and a proline-rich domain involved in intracellular transport and reverse signaling.

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