The search for compounds to rescue the biosynthesis of DF508-CFTR has become a major goal of the Cystic Fibrosis research community. The Cystic Fibrosis Foundation has partnered with several pharmaceutical companies in an effort to achieve this goal. Hundreds of thousands of compounds have...

Bone is involved in the maintenance of phosphate and vitamin D homeostasis via its production and secretion of FGF23 and serves as a reservoir for the storage and release of calcium and phosphate into the circulation. Alterations in mineralization of extracellular matrix and the remodeling...

We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage‑specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and...

This chapter will review the various biological actions of the mouse fibroblast growth factor 15 (Fgf15) and human fibroblast growth factor 19 (FGF19). Unlike other members of the fibroblast growth factor (FGF) family, the Fgf15 and FGF19 orthologs do not share a high degree of sequence...

Staphylococcus aureus remains one of the major human pathogens, causing a number of diverse infections. The growing antibiotic resistance, including vancomycin and methicilin‑resistant strains raises the special interest in virulence mechanism of this pathogen. Among a number of...

The blood‑brain barrier refers to the very low permeability across microvessels in the Central Nervous System (CNS), created by the interaction between vascular endothelial cells and surrounding cells of the neurovascular unit. Permeability can be modulated (increased and decreased) by a...