During the last decade of the 20th century a totally novel way of gene regulation was revealed. Findings that at first glance appeared freak features of plants or C. elegans turned out to be mechanistically related and deeply conserved throughout evolution. This important insight was primed by...

Homeostasis is a key feature of cellular lifespan. Maintenance of cellular homeostasis influences the rate of aging and its efficiency is determined by the cooperation between protein stability and resistance to stress, protein refolding, protein repair and proteolysis of damaged proteins....

Nasopharyngeal carcinoma (NPC) is a rare tumor in most countries but is more prevalent in Southeast Asia, circumpolar North America and northern Africa. Multiple factors participate in the etiology of NPC; they include Epstein‑Barr virus (EBV), genetic susceptibility and environmental...

From analysis of deep‑sequencing data it is apparent that sequence differences occur between the genome and miRNAs. Changes from genomic A to an apparent G in miRNA can be accounted for by the editing activity of ADARs. Questions that arise from this observation are: How many miRNAs are edited...

Cellular homeostasis, which is needed for the cells to survive, requires a well‑controlled balance in protein turnover. Both protein synthesis and degradation are influenced by distinct genetic pathways that control aging in divergent eukaryotic species. These conserved mechanisms involve the...

The discovery of the first homeotic mutation by Calvin Bridges in 19151 profoundly influenced the way we think about developmental processes. Although many mutations modify or deform morphological structures, homeotic mutations cause a spectacular phenotype in which a morphological structure...