Nasopharyngeal carcinoma (NPC) is a rare tumor in most countries but is more prevalent in Southeast Asia, circumpolar North America and northern Africa. Multiple factors participate in the etiology of NPC; they include Epstein‑Barr virus (EBV), genetic susceptibility and environmental...

From analysis of deep‑sequencing data it is apparent that sequence differences occur between the genome and miRNAs. Changes from genomic A to an apparent G in miRNA can be accounted for by the editing activity of ADARs. Questions that arise from this observation are: How many miRNAs are edited...

Cellular homeostasis, which is needed for the cells to survive, requires a well‑controlled balance in protein turnover. Both protein synthesis and degradation are influenced by distinct genetic pathways that control aging in divergent eukaryotic species. These conserved mechanisms involve the...

The discovery of the first homeotic mutation by Calvin Bridges in 19151 profoundly influenced the way we think about developmental processes. Although many mutations modify or deform morphological structures, homeotic mutations cause a spectacular phenotype in which a morphological structure...

In this chapter we review the different technologies that can be applied in the analysis of protein homeostasis and metabolism in ageing research. Special focus will be on technologies with a potential to circumvent the problems associated with cell heterogeneity in biomarker discovery. Often...

Appropriate regulation of mRNA translation is essential for growth and survival and the pathways that regulate mRNA translation have been highly conserved throughout eukaryotic evolution. Translation is controlled by a complex set of mechanisms acting at multiple levels, ranging from global...