A Comprehensive Resource in Bioscience and Biomedicine

Chapters in the Madame Curie Bioscience Database come from 303 books,
(4358 chapters, 63003 printed pages) published by Landes Bioscience. You can read and print these chapters with either an annual subscription ($99 for an individual) or per-chapter for $19 each.



Latest Madame Curie Chapters

Papain‑Like Proteases of Staphylococcus Aureus
Tomasz Kantyka, Lindsey N. Shaw and Jan Potempa

Staphylococcus aureus remains one of the major human pathogens, causing a number of diverse infections. The growing antibiotic resistance, including vancomycin and methicilin‑resistant strains raises the special interest in virulence mechanism of this pathogen. Among a number of...


The blood‑brain barrier refers to the very low permeability across microvessels in the Central Nervous System (CNS), created by the interaction between vascular endothelial cells and surrounding cells of the neurovascular unit. Permeability can be modulated (increased and decreased) by a...


Atherosclerosis, Caveolae and Caveolin‑1
Stephanos Pavlides, Jorge L. Guiterrez-Pajares, Christiane Danilo, Michael P. Lisanti and Philippe G. Frank

Atherosclerosis is a disease of the blood vessel characterized by the development of an arterial occlusion containing lipid and cellular deposits. Caveolae are 50‑100 nm cell surface plasma membrane invaginations that are believed to play an important role in the regulation of cellular...


Entamoeba Histolytica Cathepsin‑Like Enzymes: Interactions with the Host Gut
Vanessa Kissoon-Singh, Leanne Mortimer and Kris Chadee

Cysteine proteases of the protozoan parasite Entamoeba histolytica are key virulence factors involved in overcoming host defences. These proteases are cathepsin‑like enzymes with a cathepsin‑L like structure, but cathepsin‑B substrate specificity. In the host intestine, amoeba cysteine...


Kainate receptors (KARs) are glutamate‑gated ion channels, assembled from various combinations of GluK1‑GluK5 subunits with different physiological and pharmacological properties. In the hippocampus, KARs expressed at postsynaptic site mediate a small component of excitatory postsynaptic...


Proteases are the most abundant class of proteins produced by mast cells. Many of these are stored in membrane‑enclosed intracellular granules until liberated by degranulating stimuli, which include cross‑linking of high affinity IgE receptor FcεRI by IgE bound to multivalent allergen....


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