Stefan Pöhlmann
Hannover Medical School, Hannover, Germany;
German Primate Center, Göttingen, Germany

Graham Simmons
Blood Systems Research Institute
San Francisco, California, U.S.A.

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About this Book

For a virus to invade a host cell it needs to penetrate the physical barrier imposed by the plasma membrane. Viruses have evolved specialized surface proteins to meet this challenge. These proteins facilitate delivery of the viral genetic information into the host cell by either fusing the viral envelope with a host cell membrane (enveloped viruses) or by forming membrane pores (non‑enveloped viruses). Membrane fusion and pore formation critically depend on the engagement of host cell receptors and receptor choice is a key determinant of viral tropism. The multi‑faceted interplay between viral and cellular factors during virus entry is a fascinating field of study, which can provide important insight into viral pathogenesis and define new targets for intervention. This book provides a comprehensive overview of this exciting field of research.

Table of Contents

1. Attachment Factors
Clare L. Jolly and Quentin J. Sattentau

2. Picornavirus Entry
Jeffrey M. Bergelson and Carolyn B. Coyne

3. Reovirus Receptors, Cell Entry, and Proapoptotic Signaling
Pranav Danthi, Geoffrey H. Holm, Thilo Stehle and Terence S. Dermody

4. Entry of Influenza Virus
Xiangjie Sun and Gary R. Whittaker

5. Filovirus Entry
Graham Simmons

6. Paramyxovirus Entry
Katharine N. Bossart and Christopher C. Broder

7. Cellular Entry of Retroviruses
Dirk Lindemann, Imke Steffen and Stefan Pöhlmann

8. Class II Fusion Proteins
Yorgo Modis

9. Entry of Rhabdoviruses into Animal Cells
Andrew D. Regan and Gary R. Whittaker

10. Entry of Herpesviruses into Cells: The Enigma Variations
Claude Krummenacher, Andrea Carfí, Roselyn J. Eisenberg and Gary H. Cohen