Malcom Lader
King’s College London
University of London
Institute of Psychiatry at the Maudsley
London, U.K.

Daniel P. Cardinali
Universidad de Buenos Aires
Buenos Aires, Argentina

S.R. Pandi-Perumal
Comprehensive Center for Sleep Medicine
Mount Sinai School of Medicine
New York, New York, U.S.A.

Table of Contents

SECTION I: BASIC PHARMACOLOGY

1. GABAA Receptor Subtypes in Sedation and Hypnosis
Esa R. Korpi

2. Sleep Hippocampal Theta Rhythm and Sensory Processing
Marisa Pedemonte and Ricardo A. Velluti

3. Monoaminergic Mechanisms in the Regulation of Sleep-Wakefulness: Special Emphasis on Preoptic Noradrenergic System
Vijay Ramesh and Velayudhan Mohan Kumar

4. REM Sleep Function and Brain Monoamine Regulation: An Application of the Search Activity Concept
Vadim S. Rotenberg

5. Role of Wakefulness Area in the Brainstem Reticular Formation in Regulating Rapid Eye
Movement Sleep
Birendra N. Mallick, Satvinder Kaur, Stephen Thankachan and Dinesh Pal

6. The Mechanistic Relationship between NREM Sleep and Anesthesia
Laura E. Nelson, Nicholas P. Franks and Mervyn Maze

SECTION II: CHRONOPHARMACOLOGY

7. Time-Dependent Psychotropic Drug Effects: Hints of Pharmacochronomics, Broader than Circadian Time Structures
Haruo Nagayama, Germaine Cornélissen, S.R. Pandi-Perumal and Franz Halberg

8. Melatonin Interaction with BZ-GabaA Receptors: Implications for Sleep Induction
Lennard P. Niles

9. Melatonin: A Chronobiotic that Not Only Shifts Rhythms
Dieter Kunz and Richard Mahlberg

10. Melatonin and Human Sleep
Irina V. Zhdanova

11. Melatonin Efficacy to Treat Circadian Alterations of Sleep in Alzheimer’s Disease
Daniel P. Cardinali, Analía M. Furio, Luis I. Brusco and Cynthia Liberczuk

12. Pharmacotherapy for Seasonal Affective Disorder
Timo Partonen

13. Use and Discontinuation of Hypnosedative Medications
Mirko Petrovic

SECTION III: CLINICAL PHARMACOLOGY

14. Long-Term Use of Sleeping Pills in Chronic Insomnia
Milton Kramer

15. Risks of Chronic Hypnotic Use
Daniel F. Kripke

16. Effects of Psychotropics on Driving Performance
Henry J. Moller, Colin M. Shapiro and Leonid Kayumov

17. Diagnosis, Pathophysiology and Treatment of Hypersomnias
Sebastiaan Overeem and Michel Billiard

18. Chronic Disease and Sleep Architecture: Pharmacotherapeutic Considerations
James J. Herdegen

19. Benzodiazepines for Sedation in Infants and Children
Eugene Ng and Vibhuti Shah

20. The Pharmacological Management of Fatigue and Sleepiness in Affective Disorders
Karl Doghramji

21. Next-Day Residual Effects of Sleeping Medications on Driving Ability: A Review of the Literature
Joris C. Verster, Marinus N. Verbaten and Edmund R. Volkerts

22. Sleep and Pain
Wilfred R. Pigeon, Hyung Park and Michael J. Sateia

23. Head Injuries and Sleep
Chanth Seyone and Babita Kara

24. Psychopharmacological Management of Restless Legs Syndrome and Periodic Limb Movements
in Sleep
Raed Hawa, Leonid Kayumov, Alan Lowe and Colin M. Shapiro

25. A Comparison of Visual Analog Scale and Categorical Ratings in Assessing the Patient’s Estimate
of Sleep Quality
Nava Zisapel, Ricardo Tarrasch and Moshe Laudon

26. The Pharmacostrategy of Treating Sleep Disorders in Parkinsonism
Jean-Jacques Askenasy

27. The Neuropharmacology of Nightmares
J.F. Pagel

28. The Night Eating Syndrome
Grethe Støa Birketvedt and Jon R. Florholmen

29. Drug Effects on Dreaming
Mehmet Yucel Agargun and Hanefi Ozbek

30. Sleep Problems in Primary Care
Alan G. Wade

31. SSRIs and Sleep in Man
Sue J. Wilson and David J. Nutt

32. Sleep and Antipsychotic Drugs in Schizophrenia Patients
Jaime M. Monti and Daniel Monti

33. Sleep and Epilepsy: From Interrelationships to Influence of Antiepileptic Drugs
António Martins da Silva, Melissa Mendez, Chun Bai and S.R. Pandi-Perumal

34. Herbal Medicines and Sleep
Marcello Spinella