Notch Signaling in Embryology and Cancer

Jörg Reichrath
Dermatology Clinic
The Saarland University Hospital
Homburg, Saar, Germany

Sandra Reichrath

This book is co-published with Springer.
Please click here to purchase this book at the Springer site.


ISBN: 978-1-4614-0898-7
Pub Date: December 22, 2011
Pages: 350
Color Pages: 8
Figures: 69
Tables: 9

About this Book

  • • Comprehensive in scope, covers an overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology
  • • Topics are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer
  • • Brings the diverse scientific and clinical fields together in one definitive and up-to-date volume


Table of Contents

1. The Molecular Basis of Notch Signaling: A Brief Overview
Sang‑Mo Kwon, Cantas Alev, Sang‑Hun Lee and Takayuki Asahara

2. The Role of Adams in Notch Signaling
Arjan J. Groot and Marc A. Vooijs

3. Metabolism and Transportation Pathways of GDP‑Fucose that are Required for the O‑Fucosylation of Notch
Tomoko Yamakawa, Tomonori Ayukawa and Kenji Matsuno

4. Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages
Gerald Udolph

5. Nepro: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex
Tetsuichiro Saito

6. Notch Signaling and Development of the Hematopoietic System
Ashley R. Sandy, Morgan Jones and Ivan Maillard

7. Notch Signaling in Lung Development and Disease
Keli Xu, Nadeem Moghal and Sean E. Egan

8. The Role of Notch Signaling in Kidney Development and Disease
Hila Barak, Kameswaran Surendran and Scott C. Boyle

9. Notch Signaling and the Developing Skeleton
Timothy J. Mead and Katherine E. Yutzey

10. Notch Signaling and the Developing Skin Epidermis
Daniela Massi and John Panelos

11. Notch Signaling and the Developing Hair Follicle
Geneviève Aubin‑Houzelstein

12. Notch Signaling and the Developing Inner Ear
Junko Murata, Katsuhisa Ikeda and Hideyuki Okano

13. Notch Signaling in Cancer Stem Cells
Jialiang Wang, Bruce A. Sullenger and Jeremy N. Rich

14. Notch Signaling Pathway and Cancer Metastasis
Yi‑Yang Hu, Min‑Hua Zheng, Rui Zhang, Ying‑Min Liang and Hua Han

15. Notch, Apoptosis and Cancer
Thao P. Dang

16. Ligand‑Dependent Notch Signaling in Vascular Formation
Tsutomu Kume

17. Notch and the p53 Clan of Transcription Factors
Klaus Roemer

18. Notch Signaling and Breast Cancer
Michael Reedijk

19. Notch Signaling and Malignant Melanoma
Cornelia S.L. Müller

20. Notch‑Signaling and Nonmelanoma Skin Cancer: An Ancient Friend, Revisited
Jörg Reichrath and Sandra Reichrath

21. Notch Signaling and Intestinal Cancer
Sandra Guilmeau

22. Notch Signaling and Brain Tumors
Marie‑Thérése Stockhausen, Karina Kristoffersen and Hans Skovgaard Poulsen

23. Notch Inhibition as a Promising New Approach to Cancer Therapy
Benjamin Purow

 

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