Naturally Occurring Antibodies (NAbs)

Hans U. Lutz
Institute of Biochemistry, ETH Zurich, ETH-Hönggerberg, Zurich, Switzerland

This book is co-published with Springer.
Please click here to purchase this book at the Springer site.


ISBN: 978-1-4614-3460-3
Pub Date: April 16, 2012
Pages: 290
Color Pages: 4
Figures: 46
Tables: 7

About this Book

•  Comprehensive in scope

•  With contributions by international experts

•  Illustrates the functional properties of NAbs


Table of Contents

SECTION I: NAbs IN TISSUE REPAIR AND TISSUE HOMEOSTASIS

1. Naturally Occurring IgM Antibodies to Oxidation‑Specific Epitopes
Christoph J. Binder

2. Naturally Occurring Autoantibodies to Apoptotic Cells
Keith B. Elkon and Gregg J. Silverman

3. Naturally Occurring Antibodies Directed against Carbohydrate Tumor Antigens
Reinhard Schwartz‑Albiez

4. Naturally Occurring Antibodies as Therapeutics for Neurologic Disease: Can Human Monoclonal IgMs Replace
the Limited Resource IVIG?
Arthur E. Warrington, Virginia Van Keulen, Larry R. Pease and Moses Rodriguez

5. Nature and Nurture of Catalytic Antibodies
Sudhir Paul, Stephanie A. Planque, Yasuhiro Nishiyama, Carl V. Hanson and Richard J. Massey

6. Naturally Occurring Autoantibodies in Mediating Clearance of Senescent Red Blood Cells
Hans U. Lutz

7. Naturally Occurring Autoantibodies against β‑Amyloid
Jan‑Philipp Bach and Richard Dodel

8. Multi‑Faceted Role of Naturally Occurring Autoantibodies in Fighting Pathogens
Hicham Bouhlal and Srini Kaveri

SECTION II: NAbs MODULATING AND REGULATING CELLS OF THE IMMUNE SYSTEM

9. Immunoregulation by Naturally Occurring and Disease‑Associated Autoantibodies: Binding to Cytokines and Their Role in Regulation of T‑Cell Responses
Claus H. Nielsen and Klaus Bendtzen

10. Modulation of Dendritic Cells and Tegulatory T Cells by Naturally Occurring Antibodies
Jaap Kwekkeboom

11. Control of B cells Expressing Naturally Occurring Autoantibodies
Jean Louis Pasquali and Thierry Martin

12. Granulocyte Death Regulation by Naturally Occurring Autoantibodies
Stephan von Gunten and Hans‑Uwe Simon

SECTION III: NAbs CAN INDUCE DISEASES WHEN COMPARTMENT BORDERS BREAK OR PROTEASES
DEGRADE IgG

13. Naturally Occurring Autoantibodies Mediate Ischemia/Reperfusion‑Induced Tissue Injury
Sherry D. Fleming

14. How Immune Complexes from Certain IgG NAbs and Any F(ab’)2 Can Mediate Excessive Complement Activation
Hans U. Lutz

SECTION IV: UNIQUE PROPERTIES OF NAbs

15. The Natural Autoantibody Repertoire in Newborns and Adults: A Current Overview
Asaf Madi, Sharron Bransburg‑Zabary, Dror Y. Kenett, Eshel Ben‑Jacob and Irun R. Cohen

16. Antibody Polyspecificity: What Does It Matter?
Jordan D. Dimitrov, Anastas D. Pashov and Tchavdar L. Vassilev

17. Positive and Negative Selection of Natural Autoreactive B Cells
Richard R. Hardy and Kyoko Hayakawa

18. Naturally Occurring Antibodies/Autoantibodies in Polyclonal Immunoglobulin Concentrates
Peter J. Späth and Hans U. Lutz

Advertisements