Torben Heick Jensen
aarhus University

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Books from Torben Heick Jensen

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About this Book

• Discusses the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea
• Presents recently discovered roles in the elimination of transcriptional noise and in heterochromatization
• Gives a historic perspective on the parallel discovery of the exosome and discusses the occurrence of autoantibodies to exosome components in autoimmune diseases as well as the connection of the exosome with cancer

The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of the book to introduce this fascinating protein complex and to give a timely and rich account of its many functions.

Table of Contents

1. Finding the Exosome
Phil Mitchell and David Tollervey

2. Structural Components and Architectures of RNA Exosomes
Kurt Januszyk and Christopher D. Lima

3. The Archaeal Exosome
Elena Evguenieva‑Hackenberg

4. The Exosomes of Trypanosomes and Other Protists
Christine Clayton and Antonio Estevez

5. The Exosome and 3′‑5′ RNA Degradation in Plants
Heike Lange and Dominique Gagliardi

6. Catalytic Properties of the Eukaryotic Exosome
Aleksander Chlebowski, Rafał Tomecki, María Eugenia Gas López, Bertrand Séraphin, and Andrzej Dziembowski

7. Functions of the Cytoplasmic Exosome
Daneen Schaeffer, Amanda Clark, A. Alejandra Klauer, Borislava Tsanova, and Ambro van Hoof

8. Rrp6, Rrp477 and Cofactors of the Nuclear Exosome
J. Scott Butler and Phil Mitchell

9. The Exosome and Heterochromatin: Multilevel Regulation of Gene Silencing
Sarah Coy and Lidia Vasiljeva

10. Control of Cryptic Transcription in Eukaryotes
Mathieu Rougemaille and Domenico Libri

11. The Human Exosome and Disease
Raymond H.J. Staals and Ger J.M. Pruijn