Michael Balls
Robert Combes
Nirmala Bhogal
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About this Book

• Provides valuable and detailed insight into many of the latest techniques

• Describes several techniques, which broaden the range and improve the sensitivity and relevance of toxicity endpoints, investigated both in vitro and in vivo

• Introduces new methods and systems

Table of Contents

1. Current Developments in Cell Culture Technology

Glyn Stacey

2. Embryonic Stem Cells in Safety Pharmacology and Toxicology

Tina C. Stummann and Susanne Bremer

3. Trends in Cell Culture Technology

Uwe Marx

4. Tissue Engineering in the Development of Replacement Technologies

Kevin M. Shakesheff and Felicity R.A.J. Rose

5. Toxicity Testing of Nanomaterials

Amanda M. Schrand, Liming Dai, John J. Schlager and Saber M. Hussain

6. Physiologically‑Based Pharmacokinetic (PBPK) Models in Toxicity Testing and Risk Assessment           

John C. Lipscomb, Sami Haddad, Torka Poet and Kannan Krishnan

7. In Silico Methods for Toxicity Prediction

Robert D. Combes

8. Luminescent Quantum Dots for Molecular Toxicology

Shivang R. Dave, Collin C. White, Terrance J. Kavanagh and Xiaohu Gao

9. Engineering Quasi‑Vivo^® In Vitro Organ Models

Tommaso Sbrana and Arti Ahluwalia

10. ECVAM and New Technologies for Toxicity Testing

Michel Bouvier d’Yvoire, Susanne Bremer, Silvia Casati, Mara Ceridono, Sandra Coecke, Raffaella Corvi, Chantra Eskes, Laura Gribaldo, Claudius Griesinger, Holger Knaut, Jens P. Linge, Annett Roi and Valérie Zuang

11. Medium to High Throughput Screening: Microfabrication and Chip‑Based Technology

Yuan Wen, Xudong Zhang and Shang‑Tian Yang

12. The Use of Genomics in Model In Vitro Systems

Daniel A. Casciano

13. The Use of Integrated and Intelligent Testing Strategies in the Prediction of Toxic Hazard and in Risk Assessment

Michael Balls, Robert D. Combes and Nirmala Bhogal