Maurizio Zanetti
The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, La Jolla, California, USA

Stephen P. Schoenberger
Laboratory of Cellular Immunology,
La Jolla Institute for Allergy and Immunology,
La Jolla, California, USA

 Email This

Recipient's Email: 
 

 Books from this Editor

Books from Maurizio Zanetti

Loading...

 Close

---

Share on Facebook

About this Book

* Discusses the role of Schnurri-2, which plays a critical role in cell growth, signal transduction and lymphocyte development, in the generation of memory CD4 T cells

* Examines the role of cytokines, novel costimulatory molecules and other signals coming from the microenvironment in the generation and maintenance of memory T cells

* Looks at the generation and maintenance of memory CD8 T cells during acute or chronic viral infection

Immunological memory has fascinated microbiologists and immunologists for decades as one of the new frontiers to conquer to better understand the response to pathogens, cancer and vaccination. Over the past decade, attention has turned to the intrinsic properties of the memory T cells themselves, as it has become clear that the eradication of both infected cells and tumors requires T cells. This book is an attempt to capture the wave of discoveries associated with these recent studies. Its chapters represent a wide collection of topics related to memory T cells by laboratories that have invested their skills and knowledge to understand the biology and the principles upon which memory T cells are generated, maintained and expanded upon re-encounter with antigen. Ultimately, these studies are all aimed at a better understanding of the function of memory T cells in protection against disease.

Table of Contents

1. Memory Th1/Th2 Cell Generation Controlled by Schnurri‑2
Toshinori Nakayama and Motoko Y. Kimura

2. Transcriptional Regulation during CD8 T‑Cell Immune Responses
Ivana Munitic, César Evaristo, Hsueh Cheng Sung and Benedita Rocha

3. The Role of Interleukin‑2 in Memory CD8 Cell Differentiation
Onur Boyman, Jae‑Ho Cho and Jonathan Sprent

4. The Role of Inflammation in the Generation and Maintenance of Memory T Cells
Noah S. Butler and John T. Harty

5. The Role of OX40 (CD134) in T‑Cell Memory Generation
Andrew D. Weinberg

6. The Role of Precursor Frequency in the Differentiation of Memory T Cells: Memory by Numbers
Amanda L. Marzo, Ryan T. Sowell and Bernadette Scott

7. CD8 T‑Cell Memory Differentiation during Acute and Chronic Viral Infections
Vandana Kalia, Surojit Sarkar and Rafi Ahmed

8. Longevity of T‑Cell Memory Following Acute Viral Infection
Joshua M. Walker and Mark K. Slifka

9. Principles of Memory CD8 T‑Cells Generation in Relation to Protective Immunity
Maurizio Zanetti, Paola Castiglioni and Elizabeth Ingulli

10. Memory T cells in Rhesus Macaques
Monica Vaccari and Genoveffa Franchini

11. Memory T‑Cell Subsets in Parasitic Infections
Sara Colpitts and Phillip Scott

12. Antigen Specific Memory T Cells and Their Putative Need for the Generation of Sustained Anti‑Tumor Responses
Kory L. Alderson and William J. Murphy

13. Memory T‑Cell Responses and Survival in Human Cancer: Remember to Stay Alive
Matthieu Camus and Jérôme Galon

14. Analysis of Vaccine‑Induced T Cells in Humans with Cancer
Stefanie L. Slezak, Andrea Worschech, Ena Wang, David F Stroncek and Francesco M. Marincola

15. Memory T‑Cell Homeostasis and Senescence during Aging
Sian M. Henson and Arne N. Akbar