Nasopharyngeal Carcinoma: <br>Keys for Translational Medicine and Biology

Book Details

ISBN: 978-1-4614-5946-0
Pub Date: 7 Dec 2012
Pages: 226
Color Pages: 15
Figures: 16
Tables: 18

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Nasopharyngeal Carcinoma:
Keys for Translational Medicine and Biology

Pierre Busson
Université Paris‑Sud 11, CNRS and Institut de Cancérologie Gustave Roussy
Villejuif, France

About this Book

Although listed as a rare cancer in a majority of countries, Nasopharyngeal carcinoma (NPC) has a high incidence and appears as a serious public health problem in several highly populated areas of Southeast Asia and to a lesser extent in North Africa. Worldwide, its incidence rates at 85,000 new cases per year (Globocan 2008). Thus, in terms of incidence, among human virus-associated cancers, NPC ranks third behind liver and cervix carcinoma (750,000 and 530,000, respectively). In 2008, the mortality rate of NPC was still about 51,000 per year worldwide (Globocan).

NPC is a multifactorial disease related to dietary, viral and genetic factors. Despite fascinating biological characteristics, NPC has long been aside from the mainstream of cancer research for both scientific and socio-economical reasons. It is noteworthy that biological investigations have long been hampered by the paucity of laboratory models and the lack of data on premalignant states. However, recently, in several high incidence countries, strong economic growth and rapid progress in health care has propelled NPC on the front stage of cancer research, worldwide. Simultaneously, in other places, the identification of Head and Neck cancers associated to human papilloma viruses has renewed interest for NPC as a proxy model of viral carcinogenesis.

As explained in the title, this book intends to contribute to “translational medicine and biology”. By this, we mean a bi-directional process whose aim is to develop knowledge from basic science towards diagnostic and therapeutic applications and reciprocally to raise new questions for basic scientists. One general requirement for translational research is to establish a multidisciplinary knowledge base shared by the actors of various specialties. This is precisely the aim of the twelve chapters of this book. It will be useful for scientists, including PhD students, who want to become more familiar with the main concepts of NPC pathology, medical imaging and current therapeutics. Conversely, medical doctors who want to update their knowledge of NPC biology will benefit from chapters on viral and cellular oncogenesis.

Table of Contents

1. Diagnosis and Clinical Evaluation of Nasopharyngeal Carcinoma
Alan Soo‑Beng Khoo and Kin‑Choo Pua

2. Histopathological Diagnosis of Nasopharyngeal Carcinoma: Looking beyond the Blue Book
John Nicholls and Gerald Niedobitek

3. Descriptive, Environmental and Genetic Epidemiology of Nasopharyngeal Carcinoma
Bing‑Jian Feng

4. Epstein‑Barr Virus and the Pathogenesis of Nasopharyngeal Carcinomas
Claire Gourzones, Pierre Busson and Nancy Raab‑Traub

5. Acquired Genetic and Epigenetic Alterations in Nasopharyngeal Carcinoma
Kwok‑Wai Lo, Grace Tin‑Yun Chung and Ka‑Fai To

6. Cellular Interactions in Nasopharyngeal Carcinomas
Claire Gourzones, Jihène Klibi, Luc Friboulet, Rachid Jlidi and Pierre Busson

7. Biological Tools for NPC Population Screening and Disease Monitoring
Claire Gourzones, François‑Régis Ferrand, Benjamin Vérillaud and Pierre Busson

8. Medical Imaging of Nasopharyngeal Carcinomas: Current Tools and Applications
François Bidault

9. Radiotherapy of NPC: Current Strategies and Perspectives
John Kim

10. The Evolving Role of Systemic Therapy in Nasopharyngeal Carcinoma:
Current Strategies and Perspectives

Edwin P. Hui and Anthony T.C. Chan

11. Nasopharyngeal Carcinoma Immunotherapy: Current Strategies and Perspectives
Corey Smith and Rajiv Khanna

12. Therapeutic Induction of Apoptosis in Nasopharyngeal Carcinoma
Carlo Bastianutto, Kenneth Yip, Angela Hui, Emma Ito and Fei‑Fei Liu