TRIM/RBCC Proteins

Germana Meroni
Cluster in Biomedicine, AREA Science Park, Trieste, Italy

This book is co-published with Springer.
Please click here to purchase this book at the Springer site.


ISBN: 978-1-4614-5397-0
Pub Date: November 14, 2012
Pages: 166
Figures: 25
Tables: 6

About this Book

• Gives an overview of state‑of‑the‑art basic findings on the tripartite motif (TRIM, also known as RBCC) family members

• Discusses physiological and pathological roles of the TRIM

• Provides the foundation to contribute to foster novel discoveries in the rapidly evolving field of TRIM proteins biology

The genomic ‘golden age’ has delivered the sequence of numerous novel genes while leaving us with many unanswered questions about their function. This is particularly true for gene families as, often, members are annotated based on homology rather than function. The tripartite motif family belonged to this category, although, during the last few years, the field boosted an important wealth of biochemical, cellular and physiological breakthrough data. In the first part of this book, we attempt to offer an overview of state‑of‑the‑art basic findings on the tripartite motif (TRIM, also known as RBCC) family members and to deal in the second part with their relevant and growing physiological and pathological roles.


Table of Contents

1. Genomics and Evolution of the TRIM Gene Family
Germana Meroni

2. The Tripartite Motif: Structure and Function
Lucia Micale, Evelyne Chaignat, Carmela Fusco, Alexandre Reymond and Giuseppe Merla

3. TRIM Proteins as RING Finger E3 Ubiquitin Ligases
Kazuhiro Ikeda and Satoshi Inoue

4. PML Nuclear Bodies and Other TRIM‑Defined Subcellular Compartments
Elizabeth C. Batty, Kirsten Jensen and Paul S. Freemont

5. TRIM Involvement in Transcriptional Regulation
Florence Cammas, Konstantin Khetchoumian, Pierre Chambon and Régine Losson

6. TRIM Proteins in Cancer
Valeria Cambiaghi, Virginia Giuliani, Sara Lombardi, Cristiano Marinelli, Francesca Toffalorio and Pier Giuseppe Pelicci

7. TRIM Proteins and the Innate Immune Response to Viruses
Melvyn W. Yap and Jonathan P. Stoye

8. The Microtubule‑Associated C‑I Subfamily of TRIM Proteins and the Regulation of Polarized Cell Responses
Timothy C. Cox

9. MuRFs: Specialized Members of the TRIM/RBCC Family with Roles in the Regulation of the Trophic State
of Muscle and Its Metabolism
Olga Mayans and Siegfried Labeit

10. TRIM Proteins in Development
Francesca Petrera and Germana Meroni

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