Nasimul Ahsan
Mayo Clinic Transplant Center
Jacksonville, Florida, U.S.A.

About this Book

This book addresses one of the largest unmet needs in transplantation, the need to reduce late allograft loss. In the current era, it is reasonable to expect that most allografts will serve their recipients through their life span and death with preserved graft function the ultimate goal for all transplant recipients. However, long term allograft survival has not paralleled improvements made in short term survival. Each year a percentage of the existing organ transplant patients will lose their grafts. The problem of late allograft failure is due in part to pathogenic processes, to drug management, and to transplant patient care delivery.

This book pulls together the science in this area and serves as a resource and as a catalyst for further research. The book has been divided into sections covering the entirety of chronic allograft loss from basic science consideration to clinical implications. The goal of this book is to provide the reader with an overview of long term problems in solid organ transplantation. This overview not only includes the diagnosis of immunologic and non-immunologic causes of chronic graft loss but current management as well as novel therapies for future application. This book will make a useful contribution to the literature.

Table of Contents

Foreword
Philip F. Halloran

SECTION I. INTRODUCTION

1. Introducing Chronic Graft Failure
Harold C. Yang

2. Chronic Allograft Failure: Past, Present and Future
Basit Javaid and John D. Scandling

3. Solid Organ Transplantation—An Overview
Roy D. Bloom, Lee R. Goldberg, Andrew Y. Wang, Thomas W. Faust and Robert M. Kotloff

4. Analyzing Graft Failure in the Scientific Registry of Transplant Recipients:
The Sources and Nature of the Data Available
David M. Dickinson, Gregory N. Levine, Douglas E. Schaubel and Robert A. Wolfe

5. The Immunology of Chronic Allograft Injury
Raphael Thuillier and Roslyn B. Mannon

6. Ischemia-Reperfusion Injury: Pathophysiology and Clinical Approach
Maria Teresa Gandolfo and Hamid Rabb

7. Heat Shock Protein 47 in Chronic Allograft Nephropathy
Takashi Taguchi and Mohammed Shawkat Razzaque

8. Dendritic Cell-Based Approaches to Organ Transplantation
Andrea Meinhardt and Giuseppe Vassalli

SECTION II. HEART

9. Cardiac Allograft Vasculopathy
Jignesh K. Patel and Jon A. Kobashigawa

10. The Pathology of Heart Allograft Rejection
Jon Carthy, Heather Heine, Alice Mui and Bruce McManus

11. Experimental Gene Therapy of Heart Transplantation
Giuseppe Vassalli, Charles Seydoux, Pierre Vogt, Manuel Pascual
and Ludwig K. von Segesser

SECTION III. LUNG

12. The Basic Science of Lung Allograft Failure
Trudie Goers, Ryan Fields and Thalachallour Mohanakumar

13. The Role for Cytokine Responses in the Pathogenesis of Lung
Allograft Dysfunction
John A. Belperio, Brigette Gomperts, Samuel Weigt and Michael P. Keane

14. Diagnosis of Chronic Graft Failure after Lung Transplantation
David B. Erasmus, Andras Khoor and Cesar A. Keller

15. Treatment of Chronic Graft Failure after Lung Transplantation
Francisco G. Alvarez and Cesar A. Keller

SECTION IV. LIVER

16. Liver Transplantation—An Overview
Tiffany E. Kaiser, E. Steve Woodle and Guy W. Neff

17. Hepatic Allograft Loss: Pathogenesis, Diagnosis and Management
Mohammad Ali

18. Chronic Allograft Dysfunction—Liver
Susan Lerner, Pauline Chen and Paul Martin

19. Liver Graft Loss Due to Vascular Complications
Barbara Stange, Matthias Glanemann and Natascha C. Nüssler

20. Late Allograft Failure: Liver
Jeffrey S. Crippin

21. Liver Allograft Failure Due to Recurrent Disease—Pathology
Urmila Khettry and Atoussa Goldar-Najafi

SECTION V. INTESTINE TRANSPLANT

22. Chronic Allograft Enteropathy
Gonzalo P. Rodriguez-Laiz and Kishore R. Iyer

SECTION VI. KIDNEY

23. Renal Allograft Survival: Epidemiologic Considerations
Titte R. Srinivas and Herwig-Ulf Meier-Kriesche

24. Predictive Parameters of Renal Graft Failure
Paola Romagnani

25. Clinico-Pathological Correlations of Chronic Allograft Nephropathy
Jeremy R. Chapman

26. Recurrent Glomerular Disease in the Allograft: Risk Factors and Management
Hani M. Wadei, Xochiquetzal J. Geiger and Martin L. Mai

27. Pathology of Kidney Allograft Dysfunction
Bela Ivanyi

SECTION VII. ISLET CELL

28. Islet of Langerhans: Cellular Structure and Physiology
Amanda Jabin Gustafsson and Md. Shahidul Islam

29. Islet Transplantation
Breay W. Paty and A.M. James Shapiro

30. Metabolic Indicators of Islet Graft Dysfunction
Raquel N. Faradji, Kathy Monroy, Misha Denham, Camillo Ricordi
and Rodolfo Alejandro

SECTION VIII. PANCREAS

31. Pancreas and Islet Allograft Failure
Patrick G. Dean, Yogish Kudva and Mark D. Stegall

32. Chronic Pancreas Allograft Failure
Elizabeth K. Gross and Rainer W.G. Gruessner

33. Pathological Aspects of Pancreas Allograft Failure
John C. Papadimitriou and Cinthia B. Drachenberg

SECTION IX. INFECTIOUS DISEASE

34. The Graft: Emerging Viruses in Transplantation
Deepali Kumar and Atul Humar

35. Cytomegalovirus and Allograft Failure after Solid Organ Transplantation
Hugo Bonatti, Walter C. Hellinger and Raymund R. Razonable

36. Hepatitis C Virus Infection as a Risk Factor for Graft Loss
after Renal Transplantation
Jose M. Morales and B. Dominguez-Gil

37. Polyomavirus Type BK-Associated Nephropathy and Renal Allograft Graft Loss:
Natural History, Patho-Physiology, Diagnosis and Management
Nasimul Ahsan

38. Polyomavirus Allograft Nephropathy: Clinico-Pathological Correlations
Volker Nickeleit and Harsharan K. Singh

SECTION X. PHARMACOTHERAPY

39. Pharmacotherapeutic Options in Solid Organ Transplantation
Jennifer Trofe, Anikphe Imoagene-Oyedeji and Roy D. Bloom