Guilherme Suarez-Kurtz
Instituto Nacional de Cancer
Rio de Janeiro, Brasil

About this Book

Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occurs in distinct patterns. The organization of this book was formed by a population PGx perspective: an initial review of the evolution of human genetic diversity leads into a series of chapters dealing with the population structure, and the PGx profiles, of various peoples selected on the basis of continents, countries or particular sub-groups within a continent or country.

Table of Contents

1. The Evolution and Structure of Human Genetic Diversity
Sergio D.J. Pena

2. Controlling the Effects of Population Stratification by Admixture
in Pharmacogenetics
Eduardo Tarazona-Santos, Sara Raimondi and Silvia Fuselli

3. Admixture in North America
Esteban J. Parra

4. Pharmacogenetics in the African American Population
Howard L. McLeod

5. Pharmacogenetics of Cytochrome P450 in Hispanic Populations
Pedro Dorado, Guilherme Suarez-Kurtz and Adrián LLerena

6. Pharmacogenetic Studies in the Brazilian Population
Guilherme Suarez-Kurtz and Sergio D.J. Pena

7. Pharmacogenetics of Cytochrome P450s in African Populations:
Clinical and Molecular Evolutionary Implications
Eleni Aklillu, Collet Dandara, Leif Bertilsson and Collen Masimirembwa

8. Pharmacogenomics in the Indian Population
M. Ravindra Kumar and C. Adithan

9. Pharmacogenetics and Ethnicity: An Asian Perspective
Su Pin Choo, Suman Lal and Balram Chowbay

10. Pharmacogenetics in Chinese Population
Hong-Hao Zhou and Wei Zhang

11. Pharmacogenetics in Admixed Polynesian Populations
Rod A. Lea and Geoffrey K. Chambers

12. Pharmacogenetics, Ethnic Differences in Drug Response
and Drug Regulation
Rashmi R. Shah

13. Human Genomic Variation Studies and Pharmacogenomics
Are Critical for Global Health
Béatrice Séguin, Samina Essajee, Gerardo Jimenez-Sanchez, Peter A. Singer
and Abdallah S. Daar

14. Synopsis and Perspectives
Guilherme Suarez-Kurtz