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VEGF in Development


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Christiana Ruhrberg
Institute of Opthalmology, University College London

This book is co-published with Springer.

Please click here to purchase this book at the Springer site.

ISBN: 978-0-387-78631-5
Pub date: 2008-04-03
118 pages
15 figures
2 tables
5 color pages

About this book

This book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit. In addition, VEGFA is emerging as a versatile patterning factor for several non-endothelial cell types in vertebrates. Thus, it plays a central role during organ development at multiple levels, including blood vessel growth, vessel-mediated organ induction and tissue differentiation.

Table of contents

1. The Biology of Vascular Endothelial Cell Growth Factor Isoforms
Yin-Shan Ng

2. VEGF Receptor Signalling in Vertebrate Development
Joaquim Miguel Vieira, Christiana Ruhrberg and Quenten Schwarz

3. VEGF Gene Regulation
Marcus Fruttiger

4. Embryonic Vasculogenesis and Hematopoietic Specification
Lauren C. Goldie, Melissa K. Nix and Karen K. Hirschi

5. Role of VEGF in Organogenesis
Jody J. Haigh

6. VEGF and Endothelial Guidance in Angiogenic Sprouting
Holger Gerhardt

7. Vascular and Nonvascular Roles of VEGF in Bone Development
Christa Maes and Geert Carmeliet

8. VEGF in the Nervous System
Jeffrey M. Rosenstein, Janette M. Krum and Christiana Ruhrberg