Jörg Reichrath
Dermatology Clinic, The Saarland University Hospital

About this Book

Rapid progress in the understanding of carcinogenesis and pathology of epithelial skin cancer has led to new strategies for the prevention and treatment of these malignancies. The goal of this volume is to comprehensively cover in a highly readable overview our present knowledge of pathogenetic mechanisms and molecular biology of Basal Cell and Squamous Cell Carcinomas. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in epidemiology, histology, photobiology, immunology, cytogenetics, and molecular pathology to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for clinicians and scientists interested in the biology of Basal Cell and Squamous Cell Carcinomas.

Table of Contents

1. The Epidemiology of Basal Cell and Squamous Cell Carcinoma
Hao Wang and Thomas L. Diepgen

2. Histology of Epithelial Skin Tumors
Jörg Reichrath and Kerstin Querings

3. UV Damage and DNA Repair in Basal Cell and Squamous Cell Carcinomas
Knuth Rass

4. Papillomavirus Infections and Cancerogenesis of Squamous Cell and Basal Cell Carcinomas
Guido Bens

5. The Immune System and Nonmelanoma Skin Cancers
Elma D. Baron

6. Cytogenetics of Basal Cell Carcinoma and Squamous Cell Carcinomas
Melanie A. Carless, Kevin J. Ashton and Lyn R. Griffiths

7. The Hedgehog Signaling Pathway and Epithelial Skin Cancer
Julia Reifenberger

8. p53 Protein and Nonmelanoma Skin Cancer
Vladislava O. Melnikova and Honnavara N. Ananthaswamy

9. TGF-b Pathway and Cancerogenesis of Epithelial Skin Tumors
Miguel Quintanilla, Eduardo Pérez-Gómez, Diana Romero, Mar Pons and Jaime Renart

10. PDGF Pathways and Growth of Basal Cell and Squamous Cell Carcinomas
Jingwu Xie

11. Apoptosis and Cancerogenesis of Basal Cell and Squamous Cell Carcinoma
Peter Erb, Jingmin Ji, Marion Wernli and Stanislaw A. Büchner

12. The Role of Telomerase for Cancerogenesis of Basal Cell and Squamous Cell Carcinomas
Eva-Maria Fabricius