Trafficking Inside Cells: Pathways, Mechanisms and Regulation

Nava Segev

Editor
University of Illinois at Chicago
Chicago, Illinois, USA

Associate Editors:

Aixa Alfonso
University of Illinois

Gregory Payne
UCLA School of Medicine

Julie Donaldson
National Institutes of Health



This book is co-published with Springer.
Please click here to purchase this book at the Springer site.


ISBN: 978-0-387-93876-9
Pub Date: October 1, 2009
Pages: 468
Color Pages: 4
Figures: 72
Tables: 16

About this Book

The human body is made up of trillions of tiny cells that cannot be seen by the naked eye. The functioning units inside these cells are macromolecules that need to travel in the three-dimensional cell-space to distances ten thousand times their size. This movement is highly ordered, requires energy and takes place on molecular tracks that serve as a sophisticated transport system—somewhat equivalent to the multimodal rail-highway-river networks of large metropolises. All the systems of the human body depend on the efficient delivery of macromolecules to their right destination at the right time—both within and between cells. Breakdown of this traffic system results in a variety of diseases including diabetes, cancer and heart disease, as well as immunological, neurological and developmental disorders. During the last half a century, scientists have made a quantum leap in unraveling the mysteries of trafficking inside cells. The three sections of this book together cover the past, present and future of this rapidly developing and intriguing field.


Table of Contents

SECTION I. COMPARTMENTS AND PATHWAYS

1. Overview of Intracellular Compartments and Trafficking Pathways
Andrei Tokarev, Aixa Alfonso and Nava Segev

2. How We Study Protein Transport
Mary L. Preuss, Peggy Weidman and Erik Nielsen

3. The Golgi Apparatus
Zhaolin Hua and Todd R. Graham

4. The Endocytic Pathway
Elizabeth Conibear and Yuen Yi C. Tam

5. Regulated Secretion
Naveen Nagarajan, Kenneth L. Custer and Sandra Bajjalieh

SECTION II. MECHANISMS

6. Overview of Protein Trafficking Mechanisms
Giancarlo Costaguta and Gregory S. Payne

7. Entry into the Endoplasmic Reticulum: Protein Translocation, Folding and Quality Control
Sheara W. Fewell and Jeffrey L. Brodsky

8. COP-Mediated Vesicle Transport
Silvere Pagant and Elizabeth Miller

9. Clathrin-Mediated Endocytosis
Peter S. McPherson, Brigitte Ritter, and Beverly Wendland

10. Biogenesis of Dense Core Secretory Granules
Grant R. Bowman, Andrew T. Cowan and Aaron P. Turkewitz

11. Lipid Dependent Membrane Remodelling in Protein Trafficking
Priya P. Chandra and Nicholas T. Ktistakis

12. Carrier Motility
Marcin J. Wozniak and Victoria J. Allan

13. Tethering Factors
Vladimir Lupashin and Elizabeth Sztul

14. Intracellular Membrane Fusion
Dalu Xu and Jesse C. Hay

SECTION III. REGULATION AND COORDINATION WITH OTHER CELLULAR PROCESSES

15. Regulation and Coordination of Intra-Cellular Trafficking: An Overview
Julie Donaldson and Nava Segev

16. Regulation of Protein Trafficking by GTP Binding Proteins
Michel Franco, Philippe Chavrier and Florence Niedergang

17. Posttranslational Control of Protein Trafficking in the Post-Golgi Secretory and Endocytic Pathway
Robert Piper and Nia Bryant

18. Actin Doesn’t Do the Locomotion: Secretion Drives Cell Polarization
Mahasin Osman and Richard A. Cerione

19. Intracellular Trafficking and Signaling: The Role of Endocytic Rab GTPase
M. Alejandro Barbieri, Marisa J. Wainszelbaum and Philip D. Stahl

20. The Exocytic Pathway and Development
Hans Schotman and Catherine Rabouille

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