S.R. Pandi-Perumal
Comprehensive Center for Sleep Medicine
Mount Sinai School of Medicine
New York, New York, U.S.A.

Daniel P. Cardinali
Universidad de Buenos Aires
Buenos Aires, Argentina

Table of Contents

1. Mechanisms Underlying Seasonal Regulation of Melatonin Synthesis in Rodents
Valérie Simonneaux, Marie-Laure Garidou, Christophe Ribelayga and Paul Pévet

2. Oxidative Stress-Mediated Damage during in Vivo Ischemia-Reperfusion Injury:
Protective Effects of Melatonin
Russel J. Reiter, Rosa M. Sainz, Dun-Xian Tan and Juan C. Mayo

3. Melatonin and the Thyroid Gland
Andrzej Lewinski

4. The Role of Melatonin in the Development of Scoliosis
Keith M. Bagnall, Talib Rajwani, Jessie Kautz, Marc Moreau, V. James Raso, James Mahood, Ariana Daniel, Christina Demianczuk, Janet Wilson and Xaioping Wang

5. Effect of Melatonin on Life Span and Longevity
Vladimir N. Anisimov

6. Cardiovascular Effects of Melatonin
Ewa Sewerynek

7. Pineal Gland and Cancer–An Epigenetic Approach to the Control of Malignancy:
Evaluation of the Role of Melatonin
Christian Bartsch and Hella Bartsch

8. Expression and Signal Transduction Pathways of Melatonin Receptors in the Pituitary
Hana Zemkova, Ales Balik and Stanko S. Stojilkovic

9. The Role of Thermoregulation in the Soporific Effects of Melatonin: A New Perspective
Saul S. Gilbert, Cameron J. van den Heuvel, Drew Dawson and Kurt Lushington

10. The Role of Melatonin in Human Aging and Age-Related Diseases
Michal Karasek

11. Role of Endogenous and Exogenous Melatonin in Inflammation
Salvatore Cuzzocrea

12. Heterologous Modulation of Androgen Receptor Nucleo-Cytoplasmic Shuttling
by Melatonin: A Novel Mode of Regulating Androgen Sensitivity
Nava Zisapel

13. Extrapineal Melatonin: Location and Role in Pathological Processes
Igor M. Kvetnoy, Natalia S. Sinitskaya and Tatiana V. Kvetnaia

14. Sleep and Melatonin in Diurnal Species
Irina V. Zhdanova

15. The Effect of Different Wavelengths of Light in Changing the Phase
of the Melatonin Circadian Rhythm
Helen R. Wright and Leon C. Lack

16. Clinical Utility of the Antioxidant Melatonin in the Newborn
Eloisa Gitto, Russel J. Reiter, Aurelio Amodio and Ignacio Barberi

17. Diurnal 5-HT Production and Melatonin Formation
Jimo Borjigin and Jie Deng

18. Melatonin and Mitochondrial Respiration
Yuji Okatani, Akihiko Wakatsuki and Russel J. Reiter

19. Melatonin Use As a Bone-Protecting Substance
Daniel P. Cardinali, Marta G. Ladizesky, Verónica Boggio, Rodolfo A. Cutrera,
Ana I. Esquifino and Carlos Mautalen

20. Melatonin, Light and Migraine
Bruno Claustrat, Christophe Chiquet, Jocelyne Brun and Guy Chazot

21. Melatonin in Protection against Oxidative Damage Caused by Potential Carcinogens
Malgorzata Karbownik

22. Influence of Melatonin on the Health and Diseases of the Retina
Allan F. Wiechmann

23. Melatonin Synchronizes Cell Physiology through Cytoskeletal Rearrangements
Gloria Benítez-King, Gerardo Ramírez-Rodríguez, David García and Fernando Antón-Tay

24. Melatonin in Winter Depression
Arcady A. Putilov, Galena S. Russkikh and S.R. Pandi-Perumal

25. Delayed Sleep Phase Syndrome: A Melatonin Onset Disorder
Marcel G. Smits and S.R. Pandi-Perumal

26. Melatonin as an Antidepressant for Treatment of Delayed Sleep Phase Syndrome
with Comorbid Depression
Leonid Kayumov, Alan Lowe, Raed Hawa and Colin M. Shapiro