Per Magne Ueland

Table of Contents

1. Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms
Daniel Leclerc, Sahar Sibani and Rima Rozen

2. Assays for Methylenetetrahydrofolate Reductase Polymorphisms
Arve Ulvik and Per Magne Ueland

3. Biochemical Characterization of Human Methylenetetrahydrofolate Reductase and Its Common Variants
Kazuhiro Yamada and Rowena G. Matthews

4. Severe Methylenetetrahydrofolate Reductase Deficiency
Mary Ann Thomas and David S. Rosenblatt

5. Mild MTHFR Deficiency and Folate Status
Paul F. Jacques and Silvina Furlong Choumenkovitch

6. Riboflavin and Methylenetetrahydrofolate Reductase
Steinar Hustad, Jørn Schneede and Per Magne Ueland

7. The Molecular Dynamics of Abnormal Folate Metabolism and DNA Methylation: Implications for Disease Susceptibility and Progression
S. Jill James

8. Methylenetetrahydrofolate Reductase 677C‡T Polymorphism and Risk of Arterial Occlusive Disease
Mariska Klerk and Petra Verhoef

9. Methylenetetrahydrofolate Reductase and Venous Thrombosis
Miranda B.A.J. Keijzer and Martin den Heijer

10. Neural Tube Defects, Other Congenital Malformations and Single Nucleotide Polymorphisms in the 5,10 Methylenetetrahydrofolate Reductase (MTHFR) Gene: A Meta-Analysis
Stein Emil Vollset and Lorenzo D. Botto

11. Pregnancy Complications
Willianne L.D.M. Nelen and Henk J. Blom

12. Neuropsychiatric Disease and Methylenetetrahydrofolate Reductase
Björn Regland

13. Methylenetetrahydrofolate Reductase Polymorphisms and Renal Failure
Manuela Födinger and Gere Sunder-Plassmann

14. MTHFR Polymorphisms and Colorectal Neoplasia
Jimmy W. Crott and Joel B. Mason

15. Methylenetetrahydrofolate Reductase Polymorphisms: Pharmacogenetic Effects
Bernd Christian Schwahn and Rima Rozen