Richard K. Burt M.D.
Northwestern University Medical School Chief

Table of Contents

When is a Stem Cell Really a Stem Cell?
Gerald J. Spangrude

Embryonic Stem Cells: Unique Potential to Treat Autoimmune Diseases
Dan S. Kaufman and James A. Thomson

Neural Stem Cells and Oligodendrocyte Progenitors in the Central Nervous System
Jennifer A. Jackson and Diana L. Clarke

Turning Blood into Liver
Bryon E. Petersen and Neil D. Theise

Adipose Tissue-Derived Adult Stem Cells: Potential for Cell Therapy
Laura Aust, Lyndon Cooper, Blythe Devlin, Tracey du Laney, Sandra Foster, Jeffrey M. Gimble, Farshid Guilak, Yuan Di C. Halvorsen, Kevin Hicok, Amy Kloster, Henry E. Rice, Anindita Sen, Robert W. Storms and William O. Wilkison

Hematopoietic Stem Cell Biology: Relevance to Autoimmunity
Richard J. Jones

Properties and Therapeutic Potentials of Adult Stem Cells from Bone Marrow Stroma (MSCs)
Darwin J. Prockop

Regeneration of Cardiomyocytes from Bone Marrow Stem Cells and Application to Cell Transplantation Therapy
Keiichi Fukuda

Clinical Trials of Hematopoietic Stem Cells for Cardiac and Peripheral Vascular Diseases
Hiroaki Matsubara

The Stem Cell Continuum: A Plastic Plasticity
Peter J. Quesenberry, Jean-Francois Lambert, Gerald A. Colvin, Mark Dooner, Christine I. McAuliffe, Mehrdad Abedi, Deborah Greer, Delia Demers, Jan Cerny, Brian E. Moore, Evangelos Badiavas and Vincent Falanga

Adult Stem Cell Plasticity
Sean Lee and Diane S. Krause

Collection and Expansion of Stem Cells
Linda Kelley and Ian McNiece

The Extracellular Matrix as a Substrate for Stem Cell Growth and Development and Tissue Repair
Stephen F. Badylak and Mervin C. Yoder

Gene Transfer into Human Hematopoietic Stem Cells: Problems and Perspectives
Serguei Kisselev, Tatiana Seregina, Richard K. Burt and Charles J. Link

The Etiopathogenesis of Autoimmunity
Howard Amital and Yehuda Shoenfeld

Overview of Immune Tolerance Strategies
Charles J. Hackett and Helen Quill

Death Receptor-Mediated Apoptosis and Lymphocyte Homeostasis
Lixin Zheng, Richard M. Siegel, Jagan R. Muppidi, Felicita Hornung and Michael J. Lenardo

Shifting Paradigms in Peripheral Tolerance
Jonathan D. Powell and Ronald H. Schwartz

Dendritic Cells Control the Balance between Tolerance and Autoimmunity
Simon W.F. Milling and G. Gordon MacPherson

CD4+ T Regulatory Cells and Modulation of Undesired Immune Responses
Rosa Bacchetta, Megan K. Levings and Maria-Grazia Roncarolo

Major Histocompatibility Complex and Autoimmune Disease
Ursula Holzer and Gerald T. Nepom

Analyzing Complex Polygenic Traits: The Role of Non-HLA Genes in the Susceptibility to Autoimmune Disorders
Bernard R. Lauwerys and Edward K. Wakeland

Drug-Induced Autoimmunity
Robert L. Rubin and Anke Kretz-Rommel

Evidence for a Role of Infections in the Activation of Autoreactive T Cells and the Pathogenesis of Autoimmunity
J. Ludovic Croxford and Stephen D. Miller

Molecular Analysis of Immunity
Daniel Douek

Immune Reconstitution after Hematopoietic Stem Cell Transplantation
Andreas Thiel, Tobias Alexander, Christian A. Schmidt, Falk Hiepe, Renate Arnold, Andreas Radbruch, Larissa Verda and Richard K. Burt

Historical Perspective and Rationale of HSCT for Autoimmune Diseases
Alberto M. Marmont

High-Dose Immune Suppression without Hematopoietic Stem Cells for Autoimmune Diseases
Robert A. Brodsky

Autologous Stem Cell Transplantation in Animal Models of Autoimmune Diseases
D.W. van Bekkum

Allogeneic Hemopoietic Stem Cell Transplantation in Animal Models of Autoimmune Disease
Susumu Ikehara

Mobilization and Conditioning Regimens in Stem Cell Transplant for Autoimmune Diseases
Ewa Carrier and Richard K. Burt

Infection in the Hematopoeitic Stem Cell Transplant Recipient with Autoimmune Disease
Valentina Stosor and Teresa R. Zembower

Immunological Aspects of Multiple Sclerosis with Emphasis on the Potential Use of Autologous Hemopoietic Stem Cell Transplantation
Paolo A. Muraro, Henry F. McFarland and Roland Martin

Axonal Injury and Disease Progression in Multiple Sclerosis
Carl Bjartmar and Bruce D. Trapp

Monitoring Disease Activity in Multiple Sclerosis
Lorri Lobeck

Intense Immunosuppression Followed by Autologous Stem Cell Transplantation in Severe Multiple Sclerosis Cases: MRI and Clinical Data
G.L. Mancardi, R. Saccardi, A. Murialdo, F. Pagliai, F. Gualandi, A. Marmont, M. Inglese, P. Bruzzi, M.P. Sormani, M.G. Marrosu, G. Meucci, L. Massacesi, A. Bertolotto, A. Lugaresi, E. Merelli, M. Filippi and the Italian Gitmo-Neuro Intergroup on ASCT for Multiple Sclerosis

Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: Finding Equipoise
Athanasios Fassas and Richard K. Burt

Molecular and Cellular Pathogenesis of Systemic Lupus Erythematosus
George C. Tsokos, Yuang-Taung Juang, Christos G. Tsokos and Madhusoodana P. Nambiar

Definition, Classification, Activity and Damage Indices in Systemic Lupus Erythematosus
Jennifer M. Grossman and Kenneth C. Kalunian

Lupus Nephritis
Annie Y. Suh and Robert M. Rosa

Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus
Ann E. Traynor, Richard K. Burt and Alberto Marmont

Treatment of Rheumatoid Arthritis
Stuart Weisman and Arthur Kavanaugh

Haemopoietic Stem Cell Transplantation for Rheumatoid Arthritis—World Experience and Future Trials
John A. Snowden, John J. Moore, Sarah J. Bingham, Steve Z. Pavletic and Richard K. Burt

Autologous Stem Cell Transplantation for Refractory Juvenile Idiopathic Arthritis (JIA)
Nico Wulffraat

Immunology of Scleroderma
Carol M. Artlett

Hematopoietic Stem Cell Transplantation for Systemic Sclerosis
Andrew M. Yeager, Diane BuchBarker, Thomas A. Medsger, Jr. and Albert D. Donnenberg

High-Dose Immunosuppressive Chemotherapy with Autologous Stem Cell Support for Chronic Autoimmune Thrombocytopenia
Richard D. Huhn, Patrick F. Fogarty, Ryotaro Nakamura and Cynthia E. Dunbar

High-Dose Chemotherapy with Haematopoietic Stem Cell Transplantation in Primary Systemic Vasculitis, Behçet’s Disease and Sjögren’s Syndrome
Christoph Fiehn and Manfred Hensel

Hematopoietic Stem Cell Transplantation in the Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy
George Hutton, Yu Oyama, Richard K. Burt and Uday Popat

Hematopoietic Stem Cell Therapy for Patients with Refractory Myasthenia Gravis
Richard K. Burt

Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Bullous Skin Disorders
Joan Guitart and Richard K. Burt

Idiopathic Inflammatory Myositis
Yu Oyama, Walter G. Barr and Richard K. Burt

Hematopoietic Stem Cell Transplantation as Treatment for Type 1 Diabetes
Júlio C. Voltarelli, Richard K. Burt, Norma Kenyon Dixon B. Kaufman and Elizabeth C. Squiers

Autologous Hematopoietic Stem Cell Transplantation for Crohn’s Disease
Robert M. Craig and Richard K. Burt

Bronchial Asthma and Idiopathic Pulmonary Fibrosis as Potential Targets for Hematopoietic Stem Cell Transplantation
Júlio C. Voltarelli, Eduardo A. Donadi, José A. B. Martinez, Elcio O. Vianna and Willy Sarti

Autologous Stem Cell Transplantation in Relapsing Polychondritis
Falk Hiepe, Andreas Thiel, Oliver Rosen, Gero Massenkeil, Gerd-Rüdiger Burmester, Andreas Radbruch and Renate Arnold

Allogeneic Hematopoietic Stem Cell Transplantation for Autoimmune Diseases
Shimon Slavin, Alberto Marmont and Richard K. Burt