S. Clare Stanford
University College - London

About this Book

The SSRIs have had a major impact on the treatment of depression and one, Prozac, has even attained cult status. Yet, their predecessors are still used with impunity and we have no definitive explanation for their therapeutic effects. In reviewing the established and novel indications for treatment with these drugs, SSRIs: Past, Present and Future, incorporates a frank and detailed appraisal of their safety, efficacy and tolerability as well as exploring their underlying neurobiology.

Table of Contents

The Discovery Of The SSRIs: A Milestone In Neuropsychopharmacology and Rational Drug Design Arvid Carlsson

Clinical Pharmacokinetics of SSRIs Pierre Baumann, Chin B Eap and Pierre Voirol

SSRIs In Depression: Distinctive Actions? Julie Newman and Andrew A. Nierenberg

SSRIs and Patient Groups with Specific Treatment Problems John Hughes, Brian Lunn and John O’Brien

SSRIs, Drug Withdrawal and Abuse: Problem or Treatment? C. Heather Ashton and Allan H. Young

SSRIs and Sexual Function Peter A. Sargent and Guy M. Goodwin

SSRIs and Suicide John A. Henry and Carol A. Rivas

Mechanism of Action of Different Classes of Antidepressants: Evidence from 5-HT Challenge Studies Ian M. Anderson and Christopher Mortimore

SSRI-Induced Functional Changes in Serotonergic Neurons Ildefonso Hervás, Andreu Raurich, Luz Romero, Roser Cortés and Francesc Artigas

SSRI-Induced Changes in Catecholaminergic Transmission Clare Stanford

The Mechanism of Action of SSRIs: A New Hypothesis Lori L. Davis, Kimberly A. Yonkers, Madhukar Trivedi, Gerald L. Kramer and Frederick Petty

SSRIs: Where Now, Where Next? David J. Heal and Sharon C. Cheetham