Wolfgang Hilt
Institut für Biochemie Universitat Stüttgart

About this Book

This book highlights proteasome structures and how they are related to different aspects of proteasome function. Moreover, the book reports on the functional roles these highly developed proteolytic machines play within the cell. It was a great surprise to the scientific world that proteolysis provides crucial functions in cellular regulation. The surprise was even greater when it was found that not lysosomes, but protease complexes with remarkably sophisticated architectures were responsible for the control of essential regulatory events. Excitingly, proteasomes were found to be involved in widespread functions of cell physiology, which included degradation of protein waste, antigen presentation, regulation of cell metabolism and cell differentiation as well as control of the cell cycle. The discovery of such multiple and essential functions made investigation of proteasome mediated regulatory proteolysis a highly significant theme in cell biology. Written by pioneers in the field the book represents a comprehensive up-to-date view on proteasome structures and functions from the ultimate frontier of cell biology research. It ties the reader to all facets of cell function. This work is an indispensable source for scientists working in the fields of basic and applied cell biology and immunology. Different aspects of proteasome functions are associated with the development of detrimental diseases like cancer, neurodegeneration, cystic fibrosis or immune disorders. Therefore, data reviewed in this book are important for physicians and pharmacologists active in research, and experts in the pharmaceutical industry.

Table of Contents

Proteasomes: A Historical Retrospective
Dieter H Wolf

Proteasomes in Prokaryotes
Peter Zwickl, Alfred L. Goldberg, and Wolfgang Baumeister

Proteasome Crystal Structures
Matthias Bochtler, Lars Ditzel, Daniela Stock, Jan Lowe, Claudia Hartmann, Anja Dorowski, Robert Huber and Michael Groll

Subunit Arrangement in the Human Proteasome
Burkhardt Dahlmann, Klavs B. Hendil, Poul Kristensen, Wolfgang Uerkvitz, Axel Sobek and Friedrich Kopp

Active Sites and Assembly of the 20S Proteasome
Wolfgang Heinemeyer

The Regulatory Particle of the Yeast Proteasome
Michael H. Glickman, David M. Rubin, Christopher N. Larsen and Daniel Finley

The Mammalian Regulatory Complex of the 26 S Proteasome
Carlos Gorbea and Martin Rechsteinerr

The 20S Proteasome Activator PA28 or 11S Regulator
Wolfgang Dubiel and Peter Kloetzel

Proteasome Activators and Synthetic Modulators: Significance for Antigen Presentation
Sherwin Wilk, Wei-Er Chen, Cezary Wojcik and Ronald P. Magnusson

The Proteasome Inhibitors and Their Uses
Do Hee Lee and Alfred L. Goldberg

Intracellular Localization of Proteasomes
Erwin Knecht and A. Jennifer Rivett

Primary Destruction Signals
R. Jürgen Dohmen

The Ubiquitin System in Yeast
Thomas Sommer

The Ubiquitin-Proteasome Pathway in Mammals: Mechanisms of Action and
Involvement in Pathogenesis of Diseases
Aaron Ciechanover, Amir Orian and Alan L. Schwartz

Deubiquitinating Enzymes and the Regulation of Proteolysis
Rohan T. Baker

Degradation of Ornithine Decarboxylase, a Ubiquitin-Independent Proteasomal
Process Philip Coffino

The Ubiquitin-Proteasome System in Cell Cycle Control
Carl Mann and Wolfgang Hilt

p53 and the Proteasome Pathway
Martin Scheffner

The Role of the Proteasome in Apoptosis
Lisa M. Grimm and Barbara A. Osborne

Function of the Proteasome in the Protein Quality Control Process of the Endoplasmic Reticulum
Richard K. Plemper and Dieter H. Wolf

MHC Class I Antigen Presentation and the Proteasome Pathway
Peter-M. Kloetzel and Ulrike Kuckelkorn

Ubiquitin, Proteasomes and Neurodegenerative Disease
R. John Mayer, Michael Landon, James Lowe DM, Jill Fergusson, Gail Walker, Simon Dawson, Robert Layfield and Jane Arnold

The Proteasome in Posttranscriptional Control: A Protease with Endonuclease Activity?
Franck Petit, Claudia Kreutzer-Schmid, Karine Gautier, Anne-Sophie Jarrousse, Saloua Badaoui and Hans-Peter Schmid