Rahul Jandial
Division of Neurosurgery
City of Hope Cancer Center
Beckman Research Institute
Duarte-Los Angeles, California, USA

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About this Book

Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still in some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease visit our clinics.

What is the path forward? Given that the intersection of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Undeniably, medical and surgical care of cancer patients reveals biology that dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research.

This text serves as a framework for scientists to acquire clinical and translational knowledge on the complexity of disease that is metastatic cancer.

Table of Contents

SECTION I: CLINICAL CONTEXT
Edited by Lucille Leong

1. Clinical Relevance of Targeting Cancer Metastases
Lucille Leong

2. Metastases of Thoracic Origin
Jae Kim and Dan J. Raz

3. Metastatic Genitourinary Malignancies
Matthew Mei and Przemyslaw Twardowski

4. Metastatic Breast Cancer to the Brain: A Clinical Primer for Translational Investigation
Athena Anderson, Cecilia Choy, Josh Neman, Matthew J. Duenas, Rahul Jandial and George Somlo

5. Gastrointestinal Cancer Metastases: Clinical Management and Current Application of Molecular Markers
in Colorectal Carcinomas
Joseph Chao

SECTION II: BIOLOGICAL PRINCIPLES
Edited by Normand Pouliot

6. Investigating Metastasis Using In Vitro Platforms
Normand Pouliot, Helen B. Pearson and Allan Burrows

7. Modeling Metastasis In Vivo
Helen B. Pearson and Normand Pouliot

8. Genes That Mediate Metastasis Organotropism
Stefanie L. Kall and Jennifer E. Koblinski

9. Cancer Invasion and Metastasis: Molecular and Cellular Perspective
Tracey A. Martin, Lin Ye, Andrew J. Sanders, Jane Lane and Wen G. Jiang

10. Sympathetic Nervous System Regulation of Metastasis
Matthew A. Pimentel, Ming G. Chai, Caroline P. Le, Steven W. Cole and Erica K. Sloan

11. Long Non-Coding RNA: Agent Provocateur in Breast Cancer Metastasis
Richard P. Redvers and Robin L. Anderson

12. The Hematopoietic Stem Cell Niche and Bone Metastasis
Alexandra E. Forest, Yusuke Shiozawa, Kenneth J. Pienta and Russell S. Taichman

13. MicroRNAs and the Progression of Colorectal Cancer
Emily L. Paterson, Margaret Schnitzler and Gregory J. Goodall

SECTION III: INTEGRATED TRANSLATION
Edited by Rahul Jandial and Amanda Hambrecht

14. The Breast Cancer Metastases in Bone Conundrum
Walter Jackson III, Venkatesh Krishnan and Andrea M. Mastro

15. Brain Metastasis
Jae Hong Im and Ruth J. Muschel

16. Microenvironmental Landscape of Brain Metastases
Cecilia Choy, Athena Anderson, Matthew J. Duenas, Josh Neman and Rahul Jandial

17. Surgical Stress Response and Cancer Metastasis: The Potential Benefit of Perioperative Beta Blockade
John L. Raytis and Michael W. Lew

18. Tumor-Initiating Cells, Cancer Metastasis and Therapeutic Implications
Mahipal V. Suraneni and Mark D. Badeaux