Ralph H. Kehlenbach
Department of Biochemistry I
Georg-August-Universität of Göttingen
Göttingen, Germany

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About this Book

Both from a morphological and a functional point of view, the nucleus is central to modern cell biology. Transport of proteins and RNAs between the nucleus and the cytoplasm continues to be a fascinating research topic on its own. Furthermore, it affects many aspects of gene expression and general cellular functions and has far-reaching implications for human health.
In this book, we cover a wide range of topics from the nuclear transport field. Individual chapters deal with the general concepts of nucleocytoplasmic transport, with various transport pathways like nuclear protein import, mRNA export and tRNA trafficking, and with the molecular mechanisms that govern macromolecular exchange between the two compartments. Others address new technologies that will help to answer open questions in the future. Together, we hope to provide a collection of reviews that should be useful for experts in the field, as well as for a wider audience.

Table of Contents

1. Nucleocytoplasmic Transport: Players, Signals, Regulators
Ralph H. Kehlenbach

2. Nuclear Pore Complex Organization
and Nucleoporin Functions Yvonne Lussi and Birthe Fahrenkrog

3. Structural Analysis of Karyopherin‑Mediated Nucleocytoplasmic Transport
Zi Chao Zhang and Yuh Min Chook

4. At Loose Ends: A Guide to the Translocation Channel of the Nuclear Pore Complex for Dummies
David S. Goldfarb

5. Nuclear Export of Ribosomes
Arlen W. Johnson

6. Nuclear‑Cytoplasmic tRNA Trafficking
Dev Mangroo, Shawn C. Chafe, Manoja B.K. Eswara, Aaron D. Johnstone, Andrew T. McGuire and Jacqueline B. Pierce

7. mRNA Export—An Integrative Component of Gene Expression
Susanne Röther and Katja Sträßer

8. Import and Export of UsnRNPs
Achim Dickmanns

9. Transport of Inner Nuclear Membrane Proteins
Poonam Malik, Nikolaj Zuleger and Eric C. Schirmer

10. Nucleocytoplasmic Transport of Steroid Hormone Receptors
Cristina T. Kesler and Bryce M. Paschal

11. Role of the Cytoskeleton in Nucleocytoplasmic Transport
Daniela Martino Roth and David A. Jans

12. Single Substrate and Transport Receptor Molecules at the Nuclear Pore Complex
Jan‑Peter Siebrasse and Ulrich Kubitscheck