Richard Zimmermann
Saarland University
Homburg, Germany

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About this Book

Protein transport into the endoplasmic reticulum (ER) is just one aspect of the general cell biology topic of intracellular protein sorting. This larger picture also includes protein transport into other organelles of the eukaryotic cell (chloroplasts, mitochondria, nucleus, peroxisomes), protein export from bacteria, vesicular transport that delivers to its final destination most of what has been transported into the ER, and protein export from the ER that is associated with protein degradation (termed ERAD). Over the years, protein transport into the ER also has become part of the quest to understand the various roles of molecular chaperones under non-stress conditions and of the ribosomal tunnel exit as the decisive site for molecular triage of nascent polypeptide chains.

Table of Contents

1. Post‑Targeting Functions of Signal Peptides
Katja Kapp, Sabrina Schrempf, Marius K. Lemberg and Bernhard Dobberstein

2. mRNA Translation on the Endoplasmic Reticulum: Kinetic Advantages to Protein Synthesis on the ER
Samuel B. Stephens and Christopher V. Nicchitta

3. Translocon Organization in Cells
Deborah E. Aronson and Erik L. Snapp

4. Structure of the Sec61‑Complex
Richard Wagner, Frank Erdmann, Anke Harsman and Alf Honigmann

5. Sec Complexes in the Yeast ER
Barrie M. Wilkinson and Colin J. Stirling

6. The Role of BiP and Its Co‑Chaperones
Johanna Dudek, Julia Benedix and Carolin Jalal

7. Membrane Protein Biosynthesis at the Endoplasmic Reticulum
Benedict C.S. Cross and Stephen High

8. Membrane Insertion of Tail‑Anchored Proteins
Nica Borgese, Silvia Brambillasca, Marco Righi and Sara Colombo

9. Human Pathologies of Protein Transport into the Endoplasmic Reticulum
Linda Müller, Bernd Wullich and Richard Zimmermann