The Sarcomere and Skeletal Muscle Disease
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Nigel G. Laing
This book is co-published with Springer.
Please click here to purchase this book at the Springer site. ISBN: 978-0-387-84846-4 Pub date: 2008-11-03 250 pages 62 figures 17 tables 5 color pages |
About this bookAlthough best known for its role in heart disease, the sarcomere--the fundamental unit of muscle contraction--is also involved in skeletal muscle diseases. Chapters in The Sarcomere and Skeletal Muscle Disease provide an up-to-date review of diseases caused by mutated proteins in the different sub-compartments of the sarcomere, document the techniques currently being used to investigate the pathobiological bases of the diseases, which remain largely unknown, and discuss possible therapeutic options. |
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Table of contentsForeword. Sarcomeric Disease: Advances and Some Unanswered Questions PART I. THE SARCOMERE 1. The Sarcomere and Sarcomerogenesis PART II. THIN FILAMENT DISEASES 2. Skeletal Muscle Alpha-Actin Diseases 3. Nebulin—A Giant Chameleon 4. Skeletal Muscle Disease Due to Mutations in Tropomyosin, Troponin and
Cofilin 5. Investigations into the Pathobiology of Thin-Filament Myopathies 6. Mouse Models for Thin Filament Disease PART III. THICK FILAMENT DISEASES 7. Thick Filament Diseases 8. Acute Quadriplegic Myopathy: An Acquired “Myosinopathy” PART IV. THIRD FILAMENT DISEASES 9. Third Filament Diseases PART V. Z-DISK DISEASES 10. The Z-Disk Diseases PART VI. INTERMEDIATE FILAMENT DISEASES 11. Intermediate Filament Diseases: Desminopathy 12. Muscular Integrity—A Matter of Interlinking Distinct Structures via
Plectin PART VII. TROPHIC EFFECTS 13. The Sarcomere and the Nucleus: Functional Links to Hypertrophy, Atrophy
and Sarcopenia PART VIII. OTHER ANIMAL MODELS 14. Other Model Organisms for Sarcomeric Muscle Diseases PART IX. POSSIBLE THERAPIES 15. Therapeutic Approaches for the Sarcomeric Protein Diseases |
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