Pontus Aspenström
Department of Microbiology, Tumor and Cell Biology
Karolinska Institute
Stockholm, Sweden

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Books from Pontus Aspenström

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About this Book

Cell migration is an extremely complex but also a carefully orchestrated process. It involves the constant reconstruction of the cell shape, in order to adapt to an ever‑changing plethora of external and internal stimuli. Time lapse movies of migrating cells often demonstrate a vigorous ruffling activity of the plasma membrane at the cell periphery, specifically at the forefront of the cells. From the film pictures, the motor underlying these activities might seem to be the flow of membranes and the “lipid flow model” for cell migration got a lot of attention during the eighties. The model stated that cell migration is primarily driven by a flow of lipid vesicles from the rear end to the leading end of the cells and it also stated an intimate relation between cell migration and the endocytic cycle. However, this model turned out to be, if not entirely wrong, at least incomplete, since it failed to take into account the activity of the cytoskeleton. We have barely started to recognise the mechanisms underlying the communication between the machinery for membrane dynamics and the regulators of cytoarchitecture. However, it is my sincere hope that this book will help to convince the reader that numerous vital cellular processes occur at the interface between lipid bilayers and proteins.

Table of Contents

1. Boomerangs, Bananas and Blimps: Structure and Function of F‑BAR Domains in the Context of the BAR Domain Superfamily
Adam Frost, Vinzenz M. Unger and Pietro De Camilli

2. F‑BAR Domain Proteins in Schizosaccharomyces pombe
Rachel H Roberts‑Galbraith and Kathleen L. Gould

3. The Budding Yeast PCH/F‑BAR Proteins
Alan L. Munn and Barbara A.T. Winsor

4. The PACSIN Proteins and Their Role in Membrane Trafficking
Markus Plomann, Matthias Mörgelin and Sylvia Schael

5. PSTPIP1 and PSTPIP2/MAYP
Violeta Chitu and E. Richard Stanley

6. The CIP4 Family of F‑BAR Domain‑Containing Proteins
Marcia Toguchi and Pontus Aspenström

7. The NOSTRIN Subfamily of PCH/F‑BAR Proteins
Ann Siehoff‑Icking, Masood Siddique and Werner Müller‑Esterl

8. FES and FER: The F‑BAR Domain‑Containing Protein‑Tyrosine Kinases
Waheed Sangrar, Andrew W. Craig and Peter A. Greer

9. Gas7
Wenlynn B. Su, Jhong‑Jhe You, Bo‑Tsang Huang, Viswanathan Sivakumar, Shauh‑Der Yeh and Sue Lin‑Chao