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Innovative Endocrinology of Cancer


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Lev M. Berstein
Petrov Research Institute of Oncology
St. Petersburg, Russia

Richard J. Santen
University of Virginia
Charlottesville, Virginia, U.S.A.

This book is co-published with Springer.

Please click here to purchase this book at the Springer site.

ISBN: 978-0-387-78817-3
Pub date: 2008-05-12
262 pages
56 figures
14 tables
1 color pages

About this book

This volume is devoted to the new developments in such topics as mechanisms of hormonal carcinogenesis, epidemiology and risk factors, hormone production by tumor tissue and hormonal sensitivity of the latter, genesis, dichotomy and endocrinology of cancer in females, pharmacogenomics and proteomics in oncoendocrinology, biological core of hormonal and antihormonal therapy of cancer and its prevention.

Table of contents

1. Mechanisms of Hormone Carcinogenesis: Evolution of Views,
Role of Mitochondria
Jin-Qiang Chen, Terry R. Brown and James D. Yager

2. Adaptation to Estradiol Deprivation Causes Up‑Regulation of Growth Factor
Pathways and Hypersensitivity to Estradiol in Breast Cancer Cells
Richard J. Santen, Robert X. Song, Shigeru Masamura, Wei Yue, Ping Fan,
Tetsuya Sogon, Shin‑ichi Hayashi, Kei Nakachi and Hidtek Eguchi

3. Role of Endocrine‑Genotoxic Switchings in Cancer and Other Human
Diseases: Basic Triad
Lev M. Berstein

4. Breast Development, Hormones and Cancer
Jose Russo and Irma H. Russo

5. Epidemiology of Hormone‑Associated Cancers as a Reflection of Age
Svetlana V. Ukraintseva, Konstantin G. Arbeev and Anatoli I. Yashin

6. Obesity and Diabetes Epidemics: Cancer Repercussions
Anette Hjartåker, Hilde Langseth and Elisabete Weiderpass

7. Progesterone Receptor Action: Translating Studies in Breast Cancer Models
to Clinical Insights
Carol A. Lange, Carol A. Sartorius, Hany Abdel‑Hafiz, Monique A. Spillman,
Kathryn B. Horwitz and Britta M. Jacobsen

8. Aromatase Expression in Women’s Cancers
Serdar E. Bulun and Evan R. Simpson

9. Proteomics of Cancer of Hormone‑Dependent Tissues
Darren R. Tyson and David K. Ornstein

10. Endogenous Hormone Levels and Risk of Breast, Endometrial
and Ovarian Cancers: Prospective Studies
A. Heather Eliassen and Susan E. Hankinson

11. Hormonal Heterogeneity of Endometrial Cancer
Carsten Gründker, Andreas R. Günthert and Günter Emons

12. Cell Cycle Machinery: Links with Genesis and Treatment of Breast Cancer
Alison J. Butt, C. Elizabeth Caldon, Catriona M. McNeil, Alexander Swarbrick,
Elizabeth A. Musgrove and Robert L. Sutherland

13. Selective Estrogen Modulators as an Anticancer Tool: Mechanisms
of Efficiency and Resistance
Surojeet Sengupta and V. Craig Jordan

14. Pharmacogenomics of Endocrine Therapy in Breast Cancer
Richard Weinshilboum

15. Prevention of Breast Cancer Using SERMs
Trevor J. Powles

General Conclusion