Hsiou-Chi Liou
Weill Medical College
of Cornell University
New York, New York, U.S.A.

About this Book

Since its first discovery in the early 90’s, the NF-κB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-κB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-κB/Rel transcription factor family.

Table of Contents

1. Structural Analysis of NF-κB and IκB Proteins
Tom Huxford and Gourisankar Ghosh

2. NF-κB Signal Transduction by IKK Complexes
Zhi-Wei Li and Michael Karin

3. Receptors and Adaptors for NF-κB Signaling
Shao-Cong Sun and Edward W. Harhaj

4. Cellular Dynamics of NF-κB Associated Proteins
Daliya Banerjee and Ranjan Sen

5. NF-κB in Lymphopoiesis
Estefania Claudio, Keith Brown and Ulrich Siebenlist

6. NF-κB and Immune Cell Effector Functions
Hsiou-Chi Liou, Biao Feng, Wenzhi Tian, Shuhua Cheng and Constance Y. Hsia

7. Roles of NF-κB in Autoimmunity
Stacey Garrett and Youhai H. Chen

8. The Central Role of NF-κB in the Regulation of Immunity to Infection
Cristina M. Tato and Christopher A. Hunter

9. Molecular Basis of Oncogenesis by NF-κB: From a Bird’s Eye View to a RELevant Role in Cancer
Yongjun Fan, Jui Dutta, Nupur Gupta and Céline Gélinas

10. NF-κB in Human Cancers
Elaine J. Schattner, Richard R. Furman and Alejandro Bernal

11. NF-κB in Neurons: Behavioral and Physiologic Roles in Nervous System Function
Jonathan M. Levenson, Marina Pizzi and J. David Sweatt

12. Inhibitors of NF-κB Activity: Tools for Treatment of Human Ailments
Vinay Tergaonkar, Qiutang Li and Inder M. Verma