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Nasimul Ahsan
Mayo Clinic

About this book

This book explains the means of diagnosis and treatment of polyomavirus and contains an ample outline of the history, pathology, symptoms, and treatment of diseases induced by human polyomavirus. This volume is divided into four sections which thoroughly explore the most up to date information on polyomavirus including a general discussion of the virus, exploration of transplant related pathobiology, histopathology, diagnosis, management, and pharmacotherapy, afflictions and diseases caused by polyoma-JC virus and neoplastic associations of polyomaviruses. This comprehensive text will provide the reader with information on all of the latest advancements in the area.

Table of contents

1. Polyomaviruses and Human Diseases
Nasimul Ahsan and Keerti V. Shah

2. Discovery and Epidemiology of the Human Polyomaviruses BK Virus (BKV)
and JC Virus (JCV)
Wendy A. Knowles

3. Phylogenomics and Molecular Evolution of Polyomaviruses
Keith A. Crandall, Marcos Pérez-Losada, Ryan G. Christensen,
David A. McClellan and Raphael P. Viscidi

4. Virus Receptors and Tropism
Aarthi Ashok and Walter J. Atwood

5. Serological Cross Reactivity between Polyomavirus Capsids
Raphael P. Viscidi and Barbara Clayman

6. Molecular Genetics of the BK Virus
Christopher L. Cubitt

7. Serological Diagnosis of Human Polyomavirus Infection
Annika Lundstig and Joakim Dillner

8. Human Polyomavirus JC and BK Persistent Infection
Kristina Doerries

9. Immunity and Autoimmunity Induced by Polyomaviruses: Clinical, Experimental
and Theoretical Aspects
Ole Petter Rekvig, Signy Bendiksen and Ugo Moens

10. The Pathobiology of Polyomavirus Infection in Man
Parmjeet Randhawa, Abhay Vats and Ron Shapiro

11. Polyomavirus-Associated Nephropathy in Renal Transplantation:
Critical Issues of Screening and Management
Hans H. Hirsch, Cinthia B. Drachenberg, Juerg Steiger and Emilio Ramos

12. BK Virus and Immunosuppressive Agents
Irfan Agha and Daniel C. Brennan

13. BK Virus Infection after Non-Renal Transplantation
Martha Pavlakis, Abdolreza Haririan and David K. Klassen

14. Latent and Productive Polyomavirus Infections of Renal Allografts: Volker Nickeleit, Harsharan K. Singh and Michael J. Mihatsch

15. Urine Cytology Findings of Polyomavirus Infections
Harsharan K. Singh, Lukas Bubendorf, Michael J. Mihatsch, Cinthia B. Drachenberg
and Volker Nickeleit

16. Diagnosis and Treatment of BK Virus-Associated Transplant Nephropathy
Abhay Vats, Parmjeet S. Randhawa and Ron Shapiro

17. Pharmacotherapeutic Options for the Management of Human Polyomaviruses
Julie Roskopf, Jennifer Trofe, Robert J. Stratta and Nasimul Ahsan

18. Leflunomide in Solid Organ Transplantation and Polyoma Virus Infection
Michelle A. Josephson, Basit Javaid, Pradeep V. Kadambi, Shane M. Meehan
and James W. Williams

19. JC Virus Can Infect Human Immune and Nervous System Progenitor Cells:
Implications for Pathogenesis
Jean Hou, Pankaj Seth and Eugene O. Major

20. The Polyomavirus, JCV, and Its Involvement in Human Disease
Kamel Khalili, Jennifer Gordon and Martyn K. White

21. Transforming Activities of JC Virus Early Proteins
Richard J. Frisque, Catherine Hofstetter and Shiva K. Tyagarajan

22. Polyomavirus in Human Cancer Development
Winston Lee and Erik Langhoff

23. BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association Giuseppe Barbanti-Brodano, Silvia Sabbioni, Fernanda Martini, Massimo Negrini, Alfredo Corallini and Mauro Tognon

24. Epidemiologic Studies of Polyomaviruses and Cancer: Previous Findings,
Methodologic Challenges and Future Directions
Dana E.M. Rollison