Noncoding RNAs: Molecular Biology and Molecular Medicine
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Jan Barciszewski
This book is co-published with Springer.
Please click here to purchase this book at the Springer site. ISBN: 978-0-306-47835-2 Pub date: 2003-08-15 292 pages |
About this bookGeneral inspection of a role performed in the cell by RNAs allows us to distinguish three major groups of transcripts: i) protein-coding mRNAs and ii) non-coding housekeeping and iii) regulatory RNAs. The housekeeping RNAs include RNA classes that are generally, constitutively expressed and whose presence is required for normal function and viability of the cells. On the other hand, a group of regulatory RNAs includes RNA species that are expressed at certain stages of organism development or cell differentiation or as a response to external stimuli and can affect expression of other genes on the levels of transcription or translation. Noncoding RNA transcripts form a heterogeneous class of RNAs that can not be characterized by a single specific function. Initially, the term noncoding RNA (ncRNA) was used primarily to describe polyadenylated and a capped eukaryotic RNAs transcribed by RNA polymerase II, but lacking long open reading frames. Now, this definition can be extended to cover all RNA transcripts that do not show protein-coding capacity and is sometimes used to describe any RNA that does not encode protein, including introns. This book is an in-depth look at the function of NonCoding RNAs and their relationship to molecular biology and molecular biology. This is the first book on the subject to be published. |
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Table of contentsRiboregulators and Overview Introns and Noncoding RNAs the Hidden Layer of Eukaryotic Complexity Computational Gene-Finding for Noncoding RNAs Xist RNA Associates with Chromatin and Causes Gene Silencing Dosage Compensation in Drosophilae a Ribonucleoprotein Complex Mediates
Transcriptional Up-Regulation The Structure Regulation and Function of the Imprinted H19 RNA MicroRNAs Short Interfering and Micro RNAs Tiny but Mighty Post-Transcriptional Gene Silencing in Plants RNA-Directed DNA Methylation and Chromatin Modifications Brain-Specific Nonmessenger RNAs New Frontiers for the snoRNA World New Perspectives on Noncoding or Short ORF-Encoding RNAs in Plants The Noncoding Developmentally Active and Stress Inducible hsrw Gene of Drosophilae Melanogaster Integrates Post-Transcriptional Processing of Other Nuclear Adapt Gene RNA Transcripts as Riboregulators RNA Pathogenesis in Dominant Noncoding Microsatellite Expansion Disorders Noncoding RNAs Encoded by Bacterial Chromosomes We are Legion Noncoding Regulatory RNAs and Hfq |
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