Cell Cycle Checkpoints and Cancer
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Mikhail V. Blagosklonny
List price: $149.00 |
About this bookThis book addresses mechanisms of normal and cancer cell cycling, checkpoint control, the link of mitogenic signaling and cell cycle machinery. Considerable attention is devoted to the analysis of checkpoint mechanisms from yeast to man allowing us to understand the logic of the cell cycle. Applications to current and future anticancer therapies is discussed throughout the book and especially in the last chapters. |
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Table of contentsIntroductory Chapter: Advances in Research and Challenges in Therapy Autocrine Transformation: Cytokine Model Signal Transduction Pathways: Cytokine Model The Restriction Point of the Cell Cycle DNA Damage, Cell Cycle Control, and Cancer DNA Damage-Independent Checkpoints from Yeast to Man The Regulation of p53 Growth Suppression Functional Interactions Between BRCA1 and the Cell Cycle The Role of FHIT in Carcinogenesis Hypoxia and Cell Cycle G2 Checkpoint and Anticancer Therapy p53, Apoptosis, and Cancer Therapy Non-Apoptotic Responses to Anticancer Agents: Mitotic Catastrophe, Senescence,
and the Role of p53 and p21 Small Molecule Inhibitors of Cyclin-Dependent Kinases: Preclinical Cell Cycle Molecular Targets and Drug Discovery |
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