Benjamin J. Blencowe
Centre for Cellular and Biomolecular Research
University of Toronto
Toronto, Ontario, Canada

Brenton R. Graveley
University of Connecticut Health Center
Farmington, Connecticut, U.S.A.

About this Book

Alternative Splicing in the Postgenomic Era is the first book that is solely dedicated to the topic of alternative splicing. The book contains chapters by experts in the field that cover nearly all aspects of alternative splicing. The purpose of this book is to provide a single, authoritative source of information on alternative splicing that is accessible to researchers in diverse fields. The book contains information that will familiarize readers that have not previously encountered alternative splicing, but also contains sufficient depth to provide new information to experts in the field.

Table of Contents

Foreword
Phillip A. Sharp

1. Nuclear Organization and Splicing Control
Maria Carmo-Fonseca and Célia Carvalho

2. Spliceosome Assembly and Composition
Arianne J. Matlin and Melissa J. Moore

3. Relating Alternative Splicing to Proteome Complexity and Genome Evolution
Yi Xing and Christopher Lee

4. Complex Alternative Splicing
Jung Woo Park and Brenton R. Graveley

5. Technologies for the Global Discovery and Analysis of Alternative Splicing
John A. Calarco, Arneet L. Saltzman, Joanna Y. Ip and Benjamin J. Blencowe

6. Searching for Splicing Motifs
Lawrence A. Chasin

7. SR Proteins and Related Factors in Alternative Splicing
Shengrong Lin and Xiang-Dong Fu

8. hnRNP Proteins and Splicing Control
Rebeca Martinez-Contreras, Philippe Cloutier, Lulzim Shkreta, Jean-François Fisette,
Timothée Revil and Benoit Chabot

9. Functional and Mechanistic Insights From Genome-Wide Studies of Splicing
Regulation in the Brain
Jernej Ule and Robert B. Darnell

10. Regulation of Alternative Splicing by Signal Transduction Pathways
Kristen W. Lynch

11. Coupling Transcription and Alternative Splicing
Alberto R. Kornblihtt

12. The Coupling of Alternative Splicing and Nonsense-Mediated mRNA Decay
Liana F. Lareau, Angela N. Brooks, David A.W. Soergel, Qi Meng and Steven E. Brenner

13. Alternative Splicing in Disease
James P. Orengo and Thomas A. Cooper