Frank Stuart
Northwestern University Medical School

Michael Abecassis
Northwestern University Medical School

Dixon Kaufman
Northwestern University

About this Book

Organ transplantation is increasingly complex and at the same time increasingly effective. The lengthening waiting list for cadaver organs now exceeds the supply several-fold. Most practicing physicians encounter only a few transplant recipients during a year of practice. This volume was written as a quick, but comprehensive, reference for medical students, residents, fellows, nurses, and practicing physicians who interface intermittently with recipients and transplant teams. It contains twentyone chapters and twelve essays; together they present the standard of practice and also controversial issues such as the ethical dilemma of long waiting lists, noncompliance with long-term immunosuppression, the relationship between acute and chronic rejection, the living organ donor, the older cadaver donor, laparoscopic nephrectomy, retransplantation, organ banks and the national transplant network’s criteria for allocating organs to potential recipients, and the promise of xenotransplantation. Appendix I includes detailed information about immunosuppressive drugs.

Table of Contents

Immunologic Concepts
Philip F. Halloran, Thomas D. Batiuk, Nelson Goes and Patricia M. Campbell

Overview of Living and Deceased Organ Donors, Immunosuppression and Outcomes
Frank P. Stuart

Organ Allocation in the United States
Frank P. Stuart and Michael Abecassis

Organ Procurement Organizations
Stephen D. Haid, James A. Kisthard and Jarold A. Anderson

Procurement and Short-Term Preservation of Cadaveric Organs
Anthony M. D’Alessandro and James H. Southard

Kidney Transplantation
Dixon B. Kaufman, Illustrations by Simon Kimm

Pancreas Transplantation
Dixon B. Kaufman, Illustrations by Simon Kimm

Islet Transplantation
Dixon B. Kaufman, Bernhard J. Hering, Illustrations by Simon Kimm

Liver Transplantation
Michael Abecassis, Andres Blei, Alan Koffron, Steven Flamm, and Jonathan Fryer

Intestinal Transplantation
Jonathan P. Fryer

Heart Transplantation
Keith A. Horvath and David A. Fullerton

Lung Transplantation
Alberto de Hoyos and Matthew Blum

Pediatric Transplantation

Part A: Heart Transplantation
Carl L. Backer, Elfriede Pahl, Constantine Mavroudis

Part B: Kidney Transplantation
P. Stephen Almond

Part C: Liver Transplantation
Estella M. Alonso, Riccardo A. Superina

Part D: Pediatric Lung Transplantation
David A. Fullerton

Anesthesia for Organ Transplantation
Andre DeWolf, Yoogoo Kang and Laurence Sherman

Psychiatric Issues in Organ Transplantation
John E. Franklin and Roslyn M. Paine

Infections in Transplant Recipients
Valentina Stosor

Early Medical Problems Common to Many Recipients
Joseph P. Leventhal and William A. Schlueter

Late Complications of Transplantation
Bruce Kaplan and Herwig-Ulf Meier-Kriesche

Organ Transplantation Finance
Michael M. Abecassis, Dixon B. Kaufman and Frank P. Stuart

Regulatory and Fiscal Relationships between Transplant Centers and Transplant Surgeons/Physicians
Frank P. Stuart, Michael M. Abecassis and Dixon B. Kaufman

Pregnancy and Transplantation
Vincent T. Armenti, Michael J. Moritz, John S. Radomski, Gary A. Wilson, William J. Gaughan, Lisa A. Coscia and John M. Davison

Essay 1: Dominant Transplantation Tolerance
Luis Graca and Herman Waldmann

Essay 2: Antigen Receptor Revision as a Mechanism of Peripheral T Cell Tolerance
Cristine J. Cooper and Pamela J. Fink

Essay 3: T Cell Autoreactivity by Design: A Theoretical Framework for Understanding Tolerance, Autoimmunity and Transplant Rejection
Peter S. Heeger

Essay 4: Male Infertility in the Transplant Patient
Robert E. Brannigan and Robert Nadler

Essay 5: Spontaneous and Transplanted Malignancy
Israel Penn

Essay 6: Retransplantation of Vital Organs
Susan M. Lerner, Paige Porrett, James F. Markmann, and Ronald W. Busuttil

Essay 7: Noncompliance with Immunosuppressive Regimens
Thomas E. Nevins and Arthur J. Matas

Essay 8: Relationship between Acute and Chronic Rejection
Abhinav Humar and Arthur J. Matas

Essay 9: Elective and Emergency Surgery in the Stable Transplant Recipient
Amy L. Friedman, Giacomo P. Basadonna and Marc I. Lorber

Essay 10: Dental Issues before and after Organ Transplantation
Peter Hurst

Essay 11: The Living Organ Donor: Laparoscopic Donor Nephrectomy
Joseph R. Leventhal

Essay 12: Xenotransplantation
Jonathan P. Fryer, Joseph R. Leventhal

Appendix

Index